From Dr. Robert Mahley

Insights and discussion from the cutting edge with reference to journal articles and other research papers.
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Re: From Dr. Robert Mahley

Postby ApropoE4 » Sun Oct 04, 2015 8:06 pm

Gilgamesh wrote: But are we certain the correction would only take place outside neurons? (1) suggests possibly not, but I read the paper two years ago and I don't have the original with me right now.

Iirc, mitochondrial function restoration was only measured in culture. I'm guessing the researchers are aware of a shortfall when it comes to correcting apoe4 inside neurons, or they wouldn't be concerned with a separate process to restore mito function, right?

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Re: From Dr. Robert Mahley

Postby Lucy5 » Tue Oct 13, 2015 11:05 am

Bob Mahley is my hero. After I leaned my Apoe4 status I found the Gladstone group and reached out to him, NEVER thinking he'd respond to my email. My best hope - someone on his staff. But he did. In addition to being the brilliant researcher and leader in his field that we all know him to be, he is so compassionate.

I am fascinated by his work with the structure corrector and feel that for those of us who are 4/4, it may be the best way forward. An elegant solution. He gives me hope.

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Re: From Dr. Robert Mahley

Postby Stavia » Tue Oct 13, 2015 12:08 pm

We met him earlier this year. Such a kind, humble man. Totally gorgeous.

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Re: From Dr. Robert Mahley

Postby Gilgamesh » Tue Oct 13, 2015 2:34 pm

Lucy, he's my hero, too. ApropoE4: we need to get the paper and refresh our memories!


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