Fiver wrote:Hello JKramer65. Sending warm wishes your way. You got a "surprise" from the side of the family where we might have counted on a E3 or E2. What you're feeling is very normal.
It might help to know that there are many other genes and environmental factors other than E4 that play a role. Given that most of your family members were diagnosed with AD so late in life I would suspect that you also have some protective genes mixed in there....ones we don't even know about yet. Plus, you have this knowledge, this site, and modern medicine on your side.
I can say that the shock and worry does get better over time. And if you can use some of it as motivation to learn what you can and make changes to reduce your risk (and improve your overall health) then something positive comes from it.
UPDATE! Got my mother's results from 23 and me. I thought she might be e2/e4 but she is e3/e4 so curious what is in her genes to have prevented AD. She turns 92 on January 18! I'll never know my dad's (if he had one or two e4s). unless i take some of his ashes to a lab i suppose! lol. I'd be interested in in he was e4/e4. On Monday I'll know my recently diagnosed sister's status. She is meeting with a genetic counselor for a DNA review. I'll be listening in via phone. Should be interesting.
Thought you would all want to know!