A warm welcome, RHanlan!RHanlan wrote:Hi! I just got my results today. My results say that I have one ApoE4 marker; I'm only 31 right now but both my grandparents on my dads side suffered Late onset Alzheimers..... not sure how to process this information yet.....
A systematic review of 16 prospective studies concluded that physical activity decreased the risk of developing AD by 45%
Physically active ε4 carriers had an OR [odds ratio risk of Alzheimer's] of 2.30 and sedentary ε4 carriers had an OR of 5.53
Aerobic activity was associated with greater cognitive performance for ε4 carriers compared to non-carriers).
Sedentary individuals who were ε4 carriers had significantly higher levels of brain Aβ and lower levels of CSF Aβ42 compared to sedentary non-carriers, findings associated with AD pathology
...The findings also suggest that physical activity may prevent Aβ accumulation that occurs in the brains of ε4 carriers before clinical symptoms of AD even become apparent
Hello to you, Tootsie. We are grateful you have joined the ApoE4.info community and are enjoying it so far.Tootsie wrote:Hello everyone. I'm from the UK and very glad to have found this forum. I'm 53 and we lost my Mum to vascular dementia a couple of years ago at age 85. Really she had been in cognitive decline since around age 70 and I've been living with a low grade fear that I may face the same fate.
I'm involved in the Action for Happiness movement, and recently watched one of their talks by Dr Rangan Chaterjee, a supporter of the lifestyle as medicine approach for complex and chronic conditions. He briefly mentioned Dr Bredesen's work and when he said that cognitive decline was both preventable and reversible, a huge neon lightbulb went on and I had to rewind and re-listen. Oh my goodness! I just knew that this tiny piece of information was going to be very, very important to me.
I'm reading Dr Bredesen's books at the moment, and trying very hard not to dive down the rabbit hole! It is complex and there's a huge amount of information to take in. I've been lucky enough to enjoy good health thus far and when we talk about knowing our numbers.....I literally couldn't quote one! (maybe BMI/weight but that's it..) I have no idea about my genetic profile, but I may well consider testing at some point.
So I guess I'm just working through the huge amount of information and will start to come up with a plan to at least know some basic numbers and start from there. My guess would be that in the UK, most GPs wouldn't really be resourced or feel able to support this - particularly at the moment - so I'd be looking at commercial test providers and maybe a little home kit too.
I'll read on and keep learning, but Hello to you all and I'm grateful for you already! My best wishes and may you all be happy and healthy xx
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