Welcome!!!

A primer for newbies and old pros alike.
RHanlan
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Re: Welcome!!!

Postby RHanlan » Mon Feb 22, 2021 2:01 pm

Hi! I just got my results today. My results say that I have one ApoE4 marker; I'm only 31 right now but both my grandparents on my dads side suffered Late onset Alzheimers..... not sure how to process this information yet.....

NF52
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Re: Welcome!!!

Postby NF52 » Mon Feb 22, 2021 3:59 pm

RHanlan wrote:Hi! I just got my results today. My results say that I have one ApoE4 marker; I'm only 31 right now but both my grandparents on my dads side suffered Late onset Alzheimers..... not sure how to process this information yet.....
A warm welcome, RHanlan!

On behalf of everyone in the ApoE4.info community, let me tell you how glad we are that you found this forum today of all days, and posted to tell us about your news. You are absolutely right that it can be confusing to learn of an uncertain risk decades in the future, especially if you know that two generations ago (your dad's parents) they experienced Late-Onset Alzheimer's disease, the term given to a diagnosis at 65 or older.

Since this is all brand new for you, it might be helpful to know that it's normal to feel a range of emotions and even to wish you could un-learn what you know. Many of us on the site have come to believe that knowledge is power. It's empowering to have decades for lifestyle choices that have shown to be very effective in brain health! In addition, the US federal government has upped its game on AD-prevention research, with more than 3 billion dollars allocated for 2021.

We like to say "Genes are not destiny" . In fact even for people with one copy of APOE 4 who are now in their 60's or 70's, which might include your dad, a 2017 well-designed international meta-analysis found that they only had a 20-25% chance of being diagnosed with either mild cognitive impairment or Alzheimer's by the age of 85 (the current life expectancy for my generation.)

To help you explore our site, I'll share some links that I find helpful:

The Primer is written by Stavia, a practicing M.D. with ApoE4/4. It's a great place to see some strategies that you can consider--and she also recommends not trying to re-tool your entire life at once!

The How-To Guide shows how to quote members (use the " icon in the upper right of any post) so they get an email notification of your post. It also shows how to use the Search function for topics, and how to subscribe to topics of interest.

Here's a link pulled from our Wiki on Research, with a 2018 article on strategies for LOAD prevention in ApoE 4 carriers from Dr. Richard Isaacson, the Director of the Alzheimer's Prevention Program at Cornell Weill Medical Center in NYC: Clinical Application of APOE in Alzheimer’s Prevention: A Precision Medicine Approach Here's his top recommendation from the article:

Physical activity
A systematic review of 16 prospective studies concluded that physical activity decreased the risk of developing AD by 45%
Physically active ε4 carriers had an OR [odds ratio risk of Alzheimer's] of 2.30 and sedentary ε4 carriers had an OR of 5.53
Aerobic activity was associated with greater cognitive performance for ε4 carriers compared to non-carriers).
Sedentary individuals who were ε4 carriers had significantly higher levels of brain Aβ and lower levels of CSF Aβ42 compared to sedentary non-carriers, findings associated with AD pathology
...The findings also suggest that physical activity may prevent Aβ accumulation that occurs in the brains of ε4 carriers before clinical symptoms of AD even become apparent


Please reach out with questions, ideas and especially to ask for support! We're all genetic "family" here!
4/4 and still an optimist!

Tootsie
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Re: Welcome!!!

Postby Tootsie » Sat Feb 27, 2021 3:50 am

Hello everyone. I'm from the UK and very glad to have found this forum. I'm 53 and we lost my Mum to vascular dementia a couple of years ago at age 85. Really she had been in cognitive decline since around age 70 and I've been living with a low grade fear that I may face the same fate.

I'm involved in the Action for Happiness movement, and recently watched one of their talks by Dr Rangan Chaterjee, a supporter of the lifestyle as medicine approach for complex and chronic conditions. He briefly mentioned Dr Bredesen's work and when he said that cognitive decline was both preventable and reversible, a huge neon lightbulb went on and I had to rewind and re-listen. Oh my goodness! I just knew that this tiny piece of information was going to be very, very important to me.

I'm reading Dr Bredesen's books at the moment, and trying very hard not to dive down the rabbit hole! It is complex and there's a huge amount of information to take in. I've been lucky enough to enjoy good health thus far and when we talk about knowing our numbers.....I literally couldn't quote one! (maybe BMI/weight but that's it..) I have no idea about my genetic profile, but I may well consider testing at some point.

So I guess I'm just working through the huge amount of information and will start to come up with a plan to at least know some basic numbers and start from there. My guess would be that in the UK, most GPs wouldn't really be resourced or feel able to support this - particularly at the moment - so I'd be looking at commercial test providers and maybe a little home kit too.

I'll read on and keep learning, but Hello to you all and I'm grateful for you already! My best wishes and may you all be happy and healthy xx

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Jenny BC
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Re: Welcome!!!

Postby Jenny BC » Sat Feb 27, 2021 6:47 am

Tootsie wrote:Hello everyone. I'm from the UK and very glad to have found this forum. I'm 53 and we lost my Mum to vascular dementia a couple of years ago at age 85. Really she had been in cognitive decline since around age 70 and I've been living with a low grade fear that I may face the same fate.

I'm involved in the Action for Happiness movement, and recently watched one of their talks by Dr Rangan Chaterjee, a supporter of the lifestyle as medicine approach for complex and chronic conditions. He briefly mentioned Dr Bredesen's work and when he said that cognitive decline was both preventable and reversible, a huge neon lightbulb went on and I had to rewind and re-listen. Oh my goodness! I just knew that this tiny piece of information was going to be very, very important to me.

I'm reading Dr Bredesen's books at the moment, and trying very hard not to dive down the rabbit hole! It is complex and there's a huge amount of information to take in. I've been lucky enough to enjoy good health thus far and when we talk about knowing our numbers.....I literally couldn't quote one! (maybe BMI/weight but that's it..) I have no idea about my genetic profile, but I may well consider testing at some point.

So I guess I'm just working through the huge amount of information and will start to come up with a plan to at least know some basic numbers and start from there. My guess would be that in the UK, most GPs wouldn't really be resourced or feel able to support this - particularly at the moment - so I'd be looking at commercial test providers and maybe a little home kit too.

I'll read on and keep learning, but Hello to you all and I'm grateful for you already! My best wishes and may you all be happy and healthy xx
Hello to you, Tootsie. We are grateful you have joined the ApoE4.info community and are enjoying it so far.

I am sorry to hear about the loss of your Mum. I am 52 yo and lost my dad to Lewy Body Dementia last year. He was almost 76 yo. I continue to explore the rabbit holes myself both here in this wonderful forum and in the research and teachings of Dr Bredesen and his people.

I had to look up the Action for Happiness project and I am fascinated! I've heard of the scholarly work on Happiness but not this Dalai Llama sanctioned project. How amazing, and I smile as I write this as I enjoy rabbit holes immensely, but have to let up when I hit a wall so as to not get to frustrated.

I believe you are doing the right thing in taking everything in "small bites" of the information and moving forward at your own pace. It can all get potentially overwhelming quickly. There are so many wonderful people here that will help you sort through it though! I am a naturopathic doc by education here in the states, but we're only licensed in 18 of the 50 states to practice medicine, and I live in one of the 32 unlicensed states BUT I've heard it might be easier to find one in the UK. They would be well resourced in helping you determine important numbers to know, but really the ones you need to know most are the ones associated with chronic lifestyle diseases. Your fasting blood sugar for instance and other blood sugar and insulin sensitivity/resistance numbers; lipid profile - cholesterol and triglycerides, blood pressure, BMI as you mentioned, waist circumference, etc...are a good place to start. I also asked my GP run Vit D, B12, homocysteine and then hsCRP which is a marker for inflammation associated with the heart and vasculature. My hsCRP went from quite elevated to normal after significant lifestyle changes and weight loss that lowered inflammation through my whole body. WooHoo!

This link to ApoE4-Aware Healthcare Practitioners may help you find someone near you. And this How To Guide to our website should help you navigate and explore this forum to maximize your enjoyment of the experience. Other great suggestions for getting the most out of this incredible community are above in the message from nf52 to the original poster.

Explore away and please let us know if we can help.

Warmly,

Jenny
Jenny B-C ND, NBC HWC
ApoE4.info Sr Support Intern
National Board Certified Health and Wellness Coach
Naturopathic Doctor

Tootsie
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Re: Welcome!!!

Postby Tootsie » Sun Feb 28, 2021 11:15 am

Hello Jenny and thanks so much for your lovely post...I'm pleased to have introduced you to Action for Happiness! They have some interesting talks on youtube, which I've been watching recently.

Your list above is really helpful and I've decided to start with the area of insulin resistance, for which I have no idea of my numbers. I've just ordered a fasting glucose test kit, so that is baby step 1 - by the end of this week I'll know my fasting glucose level. Then I'll follow on with fasting insulin level and work out a HOMA-IR score.

For anyone (in the UK in particular) I'm finding the diabetes.co.uk forum helpful in this area and medichecks offers a fasting insulin test for £69 currently.

I won't keep posting in welcome, as that's probably not the right place...but I will keep you posted! Best wishes Tootsie


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