The ADA gene?

[Alexis]

76A12E41-D9E6-44A2-BF15-D0C9D546A2E7.png

Amidst the rather rubbish news I learnt from my 23andme data, there was also this: (attached).

Does anyone know whether this polymorphism is good or bad in the context of ApoE4?

I surmised that being a deep sleeper (which I am) might be beneficial, given the ApoE4’s need to optimise sleep.

I’ve always been someone who feels good after 6.5 hours — maybe the deep sleeping helps?

[NF52]

Hi Alexis,
I'm no expert on adenosine and the quality of sleep, but did take a look at the article referenced on 23 & me. It seems, to my layperson's eye, that the knowledge of how this one allele could interact with Apoe 4 and the quality of sleep is still emerging.
Here's a link to the full text (available in the upper right-hand part of the screen) of an article that suggests just how complicated is the relationships of sleep quality and quantity, and the neural processes of clearing toxins from the brain (including the recently discovered glymphatic system). The article recommends long-term studies of the relationships among all these factors to determine what the protective mechanisms and interventions could be. Sound like a great idea--if only someone had a ton of money!


Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease
https://www.sciencedirect.com/science/article/pii/S1087079216000186

[Alexis]

Hi Alexis,
I'm no expert on adenosine and the quality of sleep, but did take a look at the article referenced on 23 & me. It seems, to my layperson's eye, that the knowledge of how this one allele could interact with Apoe 4 and the quality of sleep is still emerging.
Here's a link to the full text (available in the upper right-hand part of the screen) of an article that suggests just how complicated is the relationships of sleep quality and quantity, and the neural processes of clearing toxins from the brain (including the recently discovered glymphatic system). The article recommends long-term studies of the relationships among all these factors to determine what the protective mechanisms and interventions could be. Sound like a great idea--if only someone had a ton of money!


Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease
https://www.sciencedirect.com/science/article/pii/S1087079216000186

Hi!

Thank you! I’ll check out the article

[AnnK]

Hi Alexis:

I'm also no expert on adenosine, but I did remember seeing a podcast by Dr. Chris Masterjohn discussing the ADA gene and coffee consumption. For reference, Dr. Masterjohn has one APOe4 allele (he did not disclose what the non-APOe4 allele was). Here's the link --

https://chrismasterjohnphd.com/2017/02/ ... save-life/

Take care and thanks for the stimulating discussion!

[Alexis]

Hi Alexis:

I'm also no expert on adenosine, but I did remember seeing a podcast by Dr. Chris Masterjohn discussing the ADA gene and coffee consumption. For reference, Dr. Masterjohn has one APOe4 allele (he did not disclose what the non-APOe4 allele was). Here's the link --

https://chrismasterjohnphd.com/2017/02/ ... save-life/

Take care and thanks for the stimulating discussion!

Great stuff — many thanks!
(Just about to drink my first cup of coffee of the day )