CurlySuze wrote:Hello, all. I have been reading articles from this website for a while, but I'm sort of cautious about joining social groups, so I just lurked for a long time. I am a 64 year old retired teacher. I learned I was APOE4/4 some years ago on 23 and Me, but since no one could give any good advice about what to do about it, I just ignored it and tried not to think about it too much. Then I heard about Dale Bredesen's work, and I started to listening to YouTubes and podcasts regarding his work and reading any articles I could find, including those on this website. When the book The End of Alzheimer's came out, I bought it and devoured it. I found a local Bredesen-trained functional physician and started seeing him. Besides doing basic blood tests, he did an organic acids test, which revealed possible gut problems. A Genova GI Effects test revealed dysbiosis and a possible borderline yeast infection, although I had virtually no symptoms (only the need for magnesium citrate for regularity).
Prior to working with my new doctor, I followed a Paleo + yogurt, butter, and cheese diet with minimal processed foods. I didn't worry too much about saturated fat back then. My blood sugar wasn't great – my A1c and blood glucose were in the low prediabetic range. I was not overweight, but had about 5 lbs that could have come off. My previous doctor (also a functional medicine physician) wasn't too worried that my lipids were pretty high since I am a female.
Once I got the dysbiosis diagnosis, I went on a low fodmap, low fiber, paleo elimination diet. I stayed on the diet for 3 months – it was miserable. I lost a lot of weight – too much – and my bowel habits (formerly on the sluggish side, but usually regular) became highly irregular. However, my blood sugar finally came down to ideal levels. And my energy levels soared, even though I was way too skinny. But my lipids, which were already too high, shot up from 275 to 332. In addition, I was unable to continue the part of the diet where you added foods back in. That would have resulted in another 5 – 10 pound weight loss, and I just couldn't sustain that.
I quit the elimination diet entirely, and started doing my own version of the mostly pescatarian somewhat vegan diet recommended by Dr. Bredesen and Dr. Gundry. I almost immediately starting putting on weight (which I needed to recover), but my blood sugar came up 5 – 10 points, my sleep deteriorated, and my energy plummeted. I'm currently having two green smoothies per day, a large bowl of cooked veggies (cruciferous and other vegetables), a large salad, and some kind of protein – either fish (2x per week), pumpkin seed protein, hemp protein, pastured beef collagen (not a complete protein), and seed mush (flax seed meal, hemp seed, coconut flakes). I am allergic to both egg white and yolk, so eggs are out. I plan to continue this diet until I have another blood test to see what changed, if anything.
Neither the paleo or pescatarian diet has hit the right mark for me. I understand that dietary recommendations are not universally agreed upon in the APOE4 world. Gundry's aversion to certain new world foods but not others, leaves me scratching my head completely... I feel certain that there's going to be a lot of variation as to what works from one person to the next. I'm wondering if anyone has figured out a way to parse this out. Has anyone used a Freestyle libre to monitor their blood sugar reactions to food, plus blood chemistry tests in order to find their perfect diet? I'd be interested in their methodology. I just know I can't go on another three month elimination diet, even though my physician says it takes that long to completely remove all the potentially offending food antigens.
Sorry for the long, drawn-out post. I welcome anyone's thoughts.
CurlySuze wrote:Hello, all.
CurlySuze wrote:It's discouraging that I felt absolutely fine before being diagnosed with a gut problem, and that nothing I've tried (Autoimmune paleo, Gundry, Bredesen style ketoflex) have given me any relief - in fact I feel worse. I'm beginning to think that working on the gut is NOT the most important thing to be doing right now.
CurlySuze wrote:It's discouraging that I felt absolutely fine before being diagnosed with a gut problem, and that nothing I've tried (Autoimmune paleo, Gundry, Bredesen style ketoflex) have given me any relief - in fact I feel worse. I'm beginning to think that working on the gut is NOT the most important thing to be doing right now. I know my methylation is poor and I've had low white blood cells for about five years. I'm wondering if I have a hidden infection(s) plus poor detox that are keeping me from making any progress. So hard to figure this out! The simple and sensible suggestions simply don't work in my case.
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