mike wrote:Think of a cell like a laundromat with a bunch of washer and dryers that are constantly on. Over time, some of the equipment may stop working, and it gets fixed. At some point, there reaches a point where it is just too broken, with water gushing. Time to take that piece of equipment off line, and completely replace with a new model. This is autophagy as an ongoing process. Now let's say that I can't afford the electricity bill anymore, so I can either go belly up (cell dies), or I can try to lower my electricity by turning off some of my machines. In this case, the laundromat will choose the older machines using the most electricity. This is autophagy as a result of lack of supplies (glucose). Our cells will clean house of less efficient materials if they can to prevent cell death. You can induce more of this by going on a fast. The longer, the more it will happen. But in ApoE4 carriers, this process is probably going on decades prior to AD symptoms because of vascular issues. Autophagy being the first stop leading to hopefully Apoptosis (controlled death) of neurons, rather than uncontrolled death with a burst of toxics coming out or cells becoming senescent, where they continue to spew toxics over time.
I love this visual! Thank you.