Julie G wrote:Hi sandyt. The short answer to your question is- NO. From what I can glean, Rhonda hasn’t studied this directly. Her theory is based on mouse and human observational study correlations and by the fact that low levels of phosphatidylcholine DHA, the precursor to DHA-lysoPC, appear to predict the occurrence of dementia. That said, I would be very hesitant to have low Omega-3 levels in the periphery given our presumed difficulty transporting it to the brain, especially as we age. For now, I find Dr. Bredesen’s observations about Rhonda’s work most helpful as far as translating it to clinical practice.
From an earlier post, these are his recommendations for us based upon her working hypothesis:So it's just a suggestion, but multiple observations fit with the idea that ApoE4 enhances the response to inflammatory insults—again, great for Tsimane Indians, bad for older Americans/Europeans/etc. (a)
1) The MFI of Milan Fiala shows that those with AD do not phagocytose their Abeta. I believe they are “keeping it active” in the circulation so it can exert its antimicrobial effect. (b)
2) Multiple genes’ transcription reduced by ApoE4 transcriptional effect lead to increased inflammation when they are reduced. (c)
3) The metabolism you mentioned—same net effect. (d)
4) The transport effect Rhonda mentioned—same net effect. This may be related to #3 as an overall response but not necessarily by the same mechanism. (e)
So, as you mentioned, how do we counter these effects?
•Increase transportable omega-3 (fish or the formulation Rhonda mentioned).
•Increase dose of omega-3.
•Reduce all sources of inflammation, such as leaky gut. As you’ve been doing, it’s key to reduce anything that would activate the hair trigger of ApoE4 to produce inflammation.
•Help resolve ongoing inflammation, even if modest, with a trial of resolvins. (f)
•Keep omega-6:omega-3 ratio optimal (about 2:1 in blood). Avoid <1 (bleeding) and >4 or so. Perhaps this should be reduced to 1:1 given that the brain may not see the same ratio?
•Target specific pathogens, as you are doing.
•Consider including other anti-inflammatories such as ginger and curcumin.
f. https://www.metagenics.com/spm-active (Recommended in The End of Alzheimer’s, pg. 199)
Thanks JulieG. So it seems that even though the omega index/ratio may not accurately reflect brain contents they still are worth knowing. I will ask my doctor for these tests at my next appointment.