circular wrote:I like they way they simplified and pulled the concepts together here and compared their approach with the FINGER, MAPT, ENLIGHTEN, and SPRINT-MIND studies.
You may have noticed Dr. Richard Isaacson as an author as well.
I agree with Circ's review!"TheresaB wrote:
NF52 wrote:… and honest about the unanswered or still open questions
In the VITACOG randomized controlled trial, including 26% ApoE4 carriers, B-vitamin
complex supplementation slowed brain atrophy by 70% in those with high baseline Hcy,
but only in the tertile with the highest serum omega-3 levels. Correspondingly, high
baseline omega-3 levels were associated with decreased brain atrophy, but only in the
B-vitamin supplementation group and not with the placebo . These data suggest
that the combination of omega-3 and sufficient B-vitamins might act synergistically to
slow cognitive decline. Data such as these suggest could also explain why omega-3
supplementation does not show benefits in all studies
Thanks for posting this, Theresa. Today I had time to relax and have a total Nerd Fest, slowly reading through this whole article. It is well-written and as you mention in your post, it has very good supporting evidence from current research for low carb and ketogenic diets as well as supplement recommendations.TheresaB wrote:This paper was just released.
Precision Nutrition for Alzheimer’s Prevention in ApoE4 Carriers
Regarding supplements, for me, this is the first time I've heard lithium recommended for ApoE4s. I've heard it recommended in general before, but not in the context of being specifically recommended for our genotype. I'd like to hear thoughts from others on their experience regarding lithium.
Welcome, Karlrad. Thanks for posting. This is an interesting take on the best diet for ApoE4’s.Karlrad wrote:In my opinion, the best diet for APOE E4/4 would consist of specific fruits and leaves, such as Ficus sycomorus figs, Ziziphus spp. fruits, Moringa spp. leaves, etc. .
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