Juliegee wrote:Here's a new paper by Dr. Roberta Brinton exploring how reduced estrogen deteriorates cerebral hypometabolism in perimenopause. As E4 carriers start in a disadvantaged place, this looks very significant for us. I'd love to see full-text.
Perimenopause as a neurological transition state
http://www.nature.com/nrendo/journal/v1 ... 15.82.htmlThe estrogen receptor network becomes uncoupled from the bioenergetic system during the perimenopausal transition and, as a corollary, a hypometabolic state associated with neurological dysfunction can develop. For some women, this hypometabolic state might increase the risk of developing neurodegenerative diseases later in life. The perimenopausal transition might also represent a window of opportunity to prevent age-related neurological diseases.
One question I keep having is … Why wouldn't the problems surface after stopping HRT after the 'window' during which it's supposed to be protective?
KatieS wrote:Cir, this does look like an interesting follow-up paper by Dr.Brinton.
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