I'd even go so far to say that if you're an ApoE4 menopausal or recently post-menopausal female, you're very foolish to not begin bio-identical HRT (especially estradiol). Dr. Trutt is my personal physician, and it looks like Silverlining has spoken to him, as well. And as SilverL has stated, Dr. Trutt does, indeed, feel very
strongly about ApoE4 women starting, and remaining indefinitely, on HRT.
That's right. I asked him flat-out during our last phone appointment how long I could remain on it. He said, point blank, "indefinitely."
And I will. Yes, I will.
Here's the thing: Trutt tested my telomeres, as well as my immune system, about four-five months after, like Julie, I *BOOM* went through the change (Menopause happens in a split second, so you're never really "menopausal"; you're either peri- or post-menopausal) extremely quickly and can pinpoint when it happened. Trutt hemmed and hawed and said, well, your telomeres are not horribly short; they're more like average, but it doesn't make sense to me because your immune system is literally spectacular. [It made perfect
sense to me, though: accelerated aging and shortened telomeres are a specific e4 issue for post-menopausal women.] I've never seen an immune system like yours in someone your age. He further explained that he places much more faith in the immune system being predictive re longevity and how fast you're aging rather than telomeres. Having said that, he continued that ApoE4 females must try to keep their telomeres as long as possible...and there's two ways to do that: take TA-65 and start HRT (estradiol).
Now, some may poo-poo TA-65 because there's only been positive results with mice studies. BUT Dr. Trutt is involved either in the middle of a human study with TA-65 or he just completed it...and it looks very promising.
Here's the thing - I'm not messing around with not
taking TA-65 while I wait for it to translate positively from rodentia to humans. I'm taking it.
And I'm so not surprised that my telomeres (some long, some short) meld into average. After all, I'm freakin' 4/4. We ApoE4 sisters age with great acceleration the minute
we stop producing - you got it - ESTROGEN. Estrogen is what keeps our lil' ol' 4 telomeres intact.
I knew I was going to do HRT the minute I read this, to me, landmark study:http://www.sciencedaily.com/releases/20 ... 173122.htm
I mean, what more evidence do we need? Is it a small study? Yes. But what OTHER study is currently dealing with female ApoE4s, their aging process, and dementia/AD prevention? So. 3/4 (and, more significantly, 4/4) peri-/post-menopausal women...please consider getting on bio-identical HRT.
My mom is 3/4 and never took HRT at all (fear of cancer). And she's 93 1/2 and experienced no true breakdown of her biomechanics until her late 80s. HOWEVER - and this is a BIG however to me - on 23andme, her three SNPs out of four point to her having long telomeres...and the fourth is average. So even though she's only 3/4, she's got a tendency towards long telomeres. See? It's not clear cut. I see it as a mel"d"ing pot, as it were.
I, on the other hand, am double 4 with two SNPs that go to long telomeres, one average, and one short. And that pretty much played out in my actual telomere test results.
So I'm banking on TA-65 and estradiol (and exercise - yes - cardio can lengthen telomeres) to lengthen, and keep lengthened, my "average" telomeres...while my really good immune system attacks any toxicity trying to pass my feeble BBB and, when it's done with that, maybe that ol' immune system will have a little energy left to destroy the AB and tau.
At least, that's what researchers are postulating.
Oh, yes. I know an overactive immune system can cause a horrendous anti-inflammatory response. I queried Trutt about that. He kind of laughed: "Lillianne, that's if you have a bad auto-immune disease. Your great immune system isn't going to be overactive. It's just going to do its job and rid you of toxins and anything harmful that could harm you or compromise your health."
So, there ya go, sisters. I say take it all. Hit this shit from ALL angles. Who cares what sticks and what doesn't?
Frankly, my mind is worth it. Don't really care what ammo is effective and what isn't...or how many different types of weapons I have to fire to render any hint of AD/dementia/Parkinson's dead and six feet under.
Until I'm six feet under.