krlentz wrote:If this has been addressed in an earlier post, I apologize -
I have the Factor V blood clot risk. I have the heterozygous mutation. No one in my extended family has ever had a blood clot. Nevertheless, my doctor will not renew my bio hrt and I doubt I could fine anyone who would. Taking matters into my own hand, I ordered some cream type products. The one I use contains .25 mg estradiol and 1 mg estriol. I use 2x - so I get .5 mg estradiol and 2 mg estriol daily. I also use a progesterone product from the same source.
Does anyone have any information (or an opinion) as to whether this dosage and the delivery method is enough to make a difference? I'm sure it's not "sufficient" to bring my levels back premenopausal levels.
Dear krlentz - mea maxima culpa for not responding before now! And I'm getting sleepy and going to bed soon, so I'll expand my post in detail later today - but I just wanted to tell you that you absolutely CAN, without a doubt, take HRT if you're a heterozygous Factor V female! I ought to know. I am...and I do.
I'll relate my sojourn at some point today wherein I researched studies and then searched high and low for a physician who would give me my her moans. I was bound and determined not to play around with this estrogen thing; hell, no. Not as an 4/4 female.
Bottom line: each and every study re asymptomatic heterozygous Factor Vs (read: no prior DVT) have shown that we have NO increased risk for a DVT when we're on bioidentical
HRT. I presented my evidence and plead my 4/4 case to a very medically conservative local and highly-touted hematologist...even argued
with him...and he STILL wouldn't give me HRT.
That's when I found, and called, Dr. Trutt at PhysioAge who knew all about ApoE4 and how very important it is that we ApoE4 females are on estradiol (bioidential estrogen). And he knew of all the aforementioned studies I had found. He chuckled and told me that, as I had found, there was no reason on Earth I couldn't take bioidentical HRT and that, as a 4/4, it was crucial that I did just that. He then said that I needed to find someone in the DC metro area (my locale) who was savvy enough to be current on this topic, and I said, hey. I need an excuse to make trips to my beloved NYC. Will you be my HRT doctor?
*bats eyelashes furiously*
He laughed some more and said, "Sure!" He's very personable.
I've been on HRT for almost a year now. And will probably never, ever stop.
So yes, Virigina, there is
an Estrogen Santa Claus. I will detail everything later today. Keep hope alive, my 4 sista. You can do this. Just not via ill-informed, haven't-kept-current-with-research-and-classes physicians.
P.S. I'm not sure if those doses are doing diddly-squat for you, kr. I'll outline my meds and doses in a subsequent post today.
P.P.S. Shout-out to my friend, the perpetually caring and lovely Julie, for bringing this to my sometimes-addled attention. Thanks, girl.