Surupe wrote:I have been spending hours upon hours trying to find studies about Testosterone and it’s effects on Apoe4 carriers. I came across this study and am curious what people think.
https://scholar.google.com/scholar?q=ne ... FaXGT413UJ
I find my menopause brain fog is just awful and appears to be getting worse. I feel hopeless and have no idea what to do. I am taking BiEst and it’s doing nothing for me. My nurse practitioner is trying to talk me into adding testosterone . Anybody here have experience with it?
Sorry to hear that you have worsening "brain fog." I tried to review your earlier posts, but may have missed some of your history. I think you mentioned "peri-menopause" earlier. Are you still having periods? If not, how long has it been?
You listed some lab results in an earlier post, but I didn't see estradiol listed. Has that not been checked? If so, what were the values?
I personally did not absorb the biest well, based on lab results. I switched to transdermal estradiol patch, which had subjective subtle improvements. Nothing dramatic. It may be worth trying the transdermal estradiol patch to see if it helps more than the biest. Stavia has an interesting story earlier in this thread on decreasing her dose of transdermal estradiol.
My testosterone (free and total) has been on the low side, but I opted out of adding on testosterone. I tend to want to minimize medical interventions if possible. My current hormone replacement is not covered by insurance. This decision was not made due to known long term issues. The information on testosterone in Bredesen's book is geared mostly towards men. The only mention I found for women is on page 209, indicating a target total testosterone between 30-70 ng/dL.
Concerning your link: it has 10 pages of references. I'm assuming that you are interested in feedback on the first article by Pfankach. The study was performed on male mice. I don't see how we can extrapolate findings to female humans.