Actually it was these posts that persuaded me to push my doctor to prescribe Menostar! But the evidence is not in. When I put in my various genes based on PLOS One study of Hormone Treatment: Estorgen Receptor Polymorphisms and Mortality: A Prospective Cohort Study (3/23/12), I have decreased risk of all-cause mortality, but a 3 -fold increase in cancer-related mortality. I'm just concerned about increasing one risk for another. If you are lucky to have the decreased risks for both, then I think the decision is easier. A very important note, is that this study was looking at hormone replacement, which is not unopposed estrogen, so like the Woman's large study, the data is skewed from progesterone and cancer risks.
The Stanford neurologist thinks it's an overgeneralization to look at my 96 y/o mother who has been on estrogen almost 50 years, since "she is a sample of ONE". This is the same guy who had headlines a few years ago, that estrogen might "put the brakes on Alzheimers for those E4 subset". He claims the studies still need to pull out these E4s to see if this in fact is the case. So in the meantime, barring side effects, I think I'l remain on the ultra-low dose, and hope that in the next few years, another study will confirm this benefit for E4s.