Bettylacy wrote::My question is when is the best time to check the level? I have in my notes that Ann wanted a trough level but whether you get it on the 3rd day or the 4th is presumably going to make a difference in the level. I have been checking mine on the 4th. Also 2nd ?
Lindajane wrote:Thanks for the info Wills Meme. I found this from The WHI study:
"Cognitive and Dementia Risks/Benefits with HT
Several observational studies and meta-analysis had suggested that estrogen prescribed to younger women at the onset of menopause decreases the risk of Alzheimer's disease or delays its onset (63, 64). In WHI, when older women (> 65 y) were studied, there was a significant detrimental effect in cognitive function in women in the E+P trial (65) and only a trend to this effect with estrogen alone (66). It has been hypothesized that the timing of initiation of HT is critical here, as it is for CHD. However, no RCT to date has been able to prove a cognitive benefit. In the recently completed KEEPS, preliminary data have suggested that there is no detrimental effect of HT, and indeed a trend to benefit in certain women (29) although this short-term trial was not designed to assess the effects of HT on cognition and dementia. While we await more definitive prospective trial data, a possible benefit based on the timing of initiation of HT is consistent with the observational studies cited above (63, 64) as well as other observational studies that focused on the timing of initiation (67–69)."
I started biodentical HRT 8 months ago and did not feel as well after starting them. I am 65 (66 next month). I am at least 10 years past menopause and I have been considering stopping the HRT. I wish there was more information for HRT in women 10 years past menopause. I certainly don't want to do something that is going to make things worse!
Lindajane wrote: I found this from The WHI study:
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