I managed to be a guest at the AAIC2018 conference in Chicago on July 23 and heard a fascinating presentation by Dr. Walter Rocca and others about HRT and AD. This is the elevator version: Since women are 2/3 of the AD patients, the disparity may be explained in part by the sudden decline in estrogen at menopause. Estrogen is necessary to metabolize lipids. If there isn't enough estrogen, the brain goes into starvation mode and starts to metabolize myelin for fuel. The WHI study that found HRT increased AD risk randomized women who were 10 years past menopause into HRT/non-HRT. But APoE4 women who start HRT at 50 and continue past the age of natural menopause may be protected. I haven't seen anything online or in media about this idea, but I keep looking. Anyone else know anything about this theory?
Waves and smiles to all my APOE sisters and brothers. I'm trying to get to that magic level of 40-60pg/ml of estradiol that Ann Hathaway recommended at the Lo Carb convention last year. I've been using transdermal for most of the >10 years of menopause. But my levels kept coming back <25 so switched to patch and have titrated up to .05mg but my levels are still <25pg/ml (checked 2x vis blood).
Plumster wrote:Hi all,
I am 48 and started progesterone as my levels were low, I'm still menstruating (not always ovulating). I want to start BHRT soon to reap the benefits. I just got my estradiol tested and it was at a good level for my cycle--i.e. not low nor too high--despite having frequent hot flashes (and significant insomnia as well as hair loss, which may be due to former low progesterone?). My question is this: When exactly is a good time to start estradiol patches/creams? Does my estradiol have to be below a certain number at a particular point of my cycle? I don't want too much estradiol, of course, but I am unclear how it is determined when to begin the therapy.
catalinda8 wrote:At 55, I'm just starting menopause -- I'd like to look into bioidentical hormones, although I'm not having hot flashes or any of the other nastier symptoms. In fact, I feel great as usual. I don't think insurance will cover bioidenticals. Is there anything I can do on my own with supplements?
jkramer65 wrote:Hi. I'm just entering this e4 world and my mind is about to explode! I am curious about HRT. I'm just 53, fine mentally and still menstruating regularly. I'm one of 3 girls. Our mother had a very late menopause (57 or 58) -- she is now 91 and fine mentally; my oldest sister who is now 68 had a hysterectomy at 33 but had ovaries and thinks she was mid 50s when she went through it. She is, so far, fine mentally; My middle sister who is 64 was recently diagnosed with AD and also had menopause around 56-57. Our father died of AD at 87. 23 and me says I'm e4/e4. That means my mom has at least one copy of 34 right? I'm the only one who has tested but working on others to do the same. Is late menopause a benefit? NOW. my mother was on HRT for years! back when it was the normal thing to do. I"m not sure when she started but I bet was on it for at least 10 years. At least until late 60s or 70.
Anyway, what is the latest on hormones? And is what ever the "latest" is different if you are e4/e4? I'm so confused by it all. I just know that right now I'm in such a tizzy about all of this -- as it is only a few months old for me -- that i'm not sure where to begin. I'm so obsessed with trying to prevent this I'm probably going to cause it! I brought it up to my gyno and she brought up the party line of risk/benefit ration blah blah blah breast cancer etc. didn't seem too open to it.
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