Julie G wrote:I know...it's a lot to take in. You're still young and may not need HRT for a while. My guess is that you'll know when you need help The symptoms were VERY severe; kinda happened overnight for me...with years of lesser symptoms leading to a crash.
The good news is that you're aware of the benefits of HRT for E4s and will be prepared when you need help.
Julie there is zero robust evidence about bio-identical hrt and long term real outcomes whatsoever. There aren't any big enough and long enough trials with 17Beta-oestradiol alone. Its all currently a theory (possibly true, possibly wishful thinking) that its safer. BUT what we do know from the Women's Health study is that oestrogen in all forms alone, without progesterone, does not increase breast cancer risk.Julie G wrote:So wonderful to hear this, Stavia!!! I understand the desire to reduce and I think it makes good physiological sense. Our reproductive systems were not meant to work into perpetuity... BUT if menopause is a symptom of aging and aging is one of the greatest risk factors for AD, it's kind of tempting to biohack this one. I'm personally planning to begin cutting back v-e-r-y slowly after 10+ years on bHRT.
Do we have evidence that bio-identical hormones contribute to cancer risk?
Absolutely Sarah. Its all n=1. I wanted to share this because I'm unexpectedly blown away by the difference in how I feel, sleep and how much sharper my cognition is within 2 days with a dose increase from 25mcg to 50mcg. I suspect there is a threshold effect in my brain, and if it is a 4/4 effect, others may be helped by my experience.sarahb12 wrote:I think, in general, we should listen to our bodies feedback. We are just beginning to understand differences between people based on genetics. I'm glad I rejected birth control pills based on subtle differences that I couldn't even verbalize, but knew they made me feel worse. Now knowing that I have the COMT variant that makes it hard to break down estrogen and harder to break down horse forms of estrogen, I have a clue why they made me feel worse.
My guess is if you have brainfog without bHRT and BHRT helps, bHRT is the better choice. But maybe not for everybody. And minimalist approach is probably the least risky. Minimum dose that does the job.
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