http://www.westonaprice.org/blogs/cmast ... thylation/
with this key paragraph...
One should then ask this question: is it better to achieve this balance by restricting methionine, or is it better to achieve this balance by adding vitamin B12, folate, vitamin B6 and glycine? The figure linked to above suggests a benefit to consuming these nutrients together: when the entire network of nutrients is present, extra methionine does not cause homocysteine to accumulate; rather, it allows the synthesis of taurine, sulfate, and glutathione. Taurine is very important to the function of the brain and retina. Sulfate is added to many compounds to regulate or detoxify them. Glutathione is the master antioxidant of the cell, one of the key compounds involved in detoxification, and a key regulator of protein function. Poor glutathione status appears to contribute to a wide array of degenerative diseases, including diabetes, asthma, and most of the negative effects that we associate with aging. Restricting methionine is one way of preventing homocysteine from accumulating; but restricting methionine compromises the supply of taurine, sulfate, and glutathione. By contrast, supplying the nutrients that synergize with methionine both prevents homocysteine from accumulating and allows the synthesis of these three incredibly important compounds.
...made even usefully simple at the end...
Instead, my practical advice is as follows:
- To the extent you eat meat, balance it with skin and bones in similar proportions as they would occur in the animal. To get a sense of these proportions, try buying whole or almost-whole animals such as roast chickens for a while.
- To the extent you eat these animal products, accompany them with rich supplies of a diverse array of plant foods, especially green leafy vegetables.
- Follow your intuition and appetite, within the restrictions of your social life and cultural ties, to the extent you operate comfortably within them.
Beyond this, in the absence of a specific problem that needs addressing, relax, and start eating food instead of analyzing it.
Of course no differential insight directly for E4's, but I'm thinking that that glutathione function is something we E4's especially want.