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a link between APP and Tau

Alzheimer's, cardiovascular, and other chronic diseases; biomarkers, lifestyle, supplements, drugs, and health care.
Doctor Lost
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a link between APP and Tau

Postby Doctor Lost » Mon Apr 27, 2015 3:55 pm

Highlights
•Neurons from different genetic forms of Alzheimer’s disease differ in APP processing
•APP mutations increase total and phosphorylated tau; PSEN1 mutations do not
•Pharmacological manipulation of APP processing changes tau protein levels
•APP regulation of tau proteostasis is not solely mediated through extracellular Aβ

http://www.cell.com/cell-reports/pdf/S2211-1247(15)00359-9.pdf

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