a link between APP and Tau

Alzheimer's, cardiovascular, and other chronic diseases; biomarkers, lifestyle, supplements, drugs, and health care.
Doctor Lost
Posts: 181
Joined: Wed Oct 30, 2013 5:37 pm

a link between APP and Tau

Postby Doctor Lost » Mon Apr 27, 2015 3:55 pm

•Neurons from different genetic forms of Alzheimer’s disease differ in APP processing
•APP mutations increase total and phosphorylated tau; PSEN1 mutations do not
•Pharmacological manipulation of APP processing changes tau protein levels
•APP regulation of tau proteostasis is not solely mediated through extracellular Aβ


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