A related news item:https://cosmosmagazine.com/life-science ... lace-table
The longest-lived mice in the best metabolic health – their heart doctors would have been happy with their blood lipid profiles, sugar, and insulin levels – were the ones eating more carbohydrates and less fat and protein. A low ratio of protein to carbs appeared to be key. The shortest-lived mice were either on a low protein, low carb, high fat diet or a high protein, high fat, low-carb diet, similar to the original Atkins diet. The mice on the Atkins-type regime were leaner, but the plumper, higher carb eating mice lived 30% longer.
The results showed that the free eating, higher carb mice lived as long as those on 40% calorie restriction, and were presumably happier too, even if they were a bit chunkier.
("The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice"
It's a rodent study, but it looks like solid work.
I'm worried about my new high-fat (65-70% by calories) diet.... The authors stress the dangers of too much protein, but too much fat was also a problem. At least I'm not eating a huge amount of protein.
This, and other work I'm currently reviewing, is actually pushing me back towards the view that lower-fat, esp. for APOE-ε4s, might be the best strategy (in general -- though we're all different!), if it can be done without concomitant problems with glucose metabolism
. As some here have pointed out, if you have to choose between bad lipids and bad glucose markers, bad glucose markers are probably (again, in general: we're all different) the bigger concern as far as AD risk is concerned.
No problem, one might think! Just choose healthy, low-GI carbs. Well, for a lot of us (like me), that doesn't do it. Any appreciable amount of carbs shoots my post-prandial glucose too high. A couple people in the CR Society eat low-fat and simply exercise after every meal. I've mentioned Dean (the "banana-eater") at the CR Society. He exercises several hours/day, including after every meal, mostly in a way (treadmill or recumbent exercycle and desk, and not very intense, but long) that enables him to work.
I find that very light aerobic exercise (getting my pulse from its post-meal resting rate of ~60 BPM [pre-meal resting rate is ~44] up to the 90s or even 80s -- haven't tested 70s) is enough to knock down glucose, and is so easy it doesn't interfere with work/concentration.
Arg. This is so frustrating! I wish we had more solid answers....