How about drinking, stress, and high BMI in late life? Headspinning
The low BMI as a risk factor scares me...
Damn lies, that last! Statistics and magic wands! No, seriously: all experienced, good researchers know that you can't control for things that make you both sick and
thin. So people with Crohn's or colitis or celiac disease or A or B or C or... (most of which are often undiagnosed and thus not controlled for) lose weight and
get AD. No surprise there. It's not the weight loss, it's the Crohn's or A or B or C that's causing the decline in health, which, in turn, increases the risk for AD. Okinawans are scrawny as hell, but live really long lives. And the rodent studies are clear on this when it comes to dementia prevention, and even the primate studies (where the lifespan effect was small, but the CR'd monkeys had almost no measurable brain atrophy).
But starting CR later in life is tricky, to be sure! One must ease into it. The initial adult-onset CR studies failed because the researchers dropped the energy-intake of the rodents (at human equiv. ages of 50-70 or so) all at once by 30+%, and weren't careful about ensuring sufficient micronutrient intake.
And we need a good test of protein status or nitrogen balance. That I do
worry about with CR in older age. Stavia, is there a reliable blood test that says something about nit. balance? I'm getting 70-80 g protein / day now on avg., nice firm BMs, so no reason to believe I'm not absorbing it as well as the next guy, exercising pretty lightly (these days) -- pulse up to 90-110 only -- 30-50 mins./day on avg. Minor weight-lifting (10-15 min. / day on avg.).
But main point, again: lies, lies, lies! In the US, having blue eyes is correlated with longer life. That doesn't mean you should try to get some crazy gene therapy or something to change your eye color (simply
) because you have brown eyes and live in the US.