Innate Immunity and Alzheimer's Risk

[marthaNH]

Seems to me somebody might have posted a link to the full text online already, but I was not able to find it. If anyone has it...

http://www.ncbi.nlm.nih.gov/pubmed/25689443

[Stavia]

I'll look later today honey.

[RichardS]

That one is from Nature-Immunology. I'm being forced to split the paper into two PDF's as the original one was too large despite my attempts to reduce the unbroken file.

[attachment]Innate immunity in Alzheimer's disease 2015a.pdf[/attachment]

The first author, Heneka, also published in the Lancet just a month later on the same topic:

[attachment]Neuroinflammation in Alzheimers disease.pdf[/attachment]

Some of it looks like heavy reading but seems like good up-to-date reviews. I have not gone past the abstracts yet.

Moderator note - I deleted the attached papers (doi:10.1038/ni.3102 doi: 10.1016/S1474-4422(15)70016-5) because our copyright infringement policy prohibits them. Members in jurisdictions for which access to Sci-Hub is legal may want to search for the papers there.

[marthaNH]

Thank you so much, Richard.

[Julie G]

Thank you, Richard! It's interesting to layer this with previous papers linking E4 with a hyper innate immune system. This also dovetails with Dr. Ram's recent paper finding E4 to be pro-inflammatory.

ApoE4 and Immunity
viewtopic.php?f=16&t=360&p=2743&hilit=Immunity#p2743