New Alzheimer's treatments may arise from modeling 'heat shock proteins'

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Tincup
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New Alzheimer's treatments may arise from modeling 'heat shock proteins'

Postby Tincup » Tue Oct 13, 2015 3:19 pm

Thanks to Rhonda Patrick:
One of the hallmarks of Alzheimer's disease is the abnormal clumping of beta-amyloid proteins in the brain, resulting in the death of brain cells. The discovery that small heat shock proteins prevent uncontrolled protein clumping has opened the possibility of developing drugs that emulate this effect. Now, a new study takes this a step further by revealing how small heat shock proteins interact with beta-amyloid to prevent clumping.
http://www.medicalnewstoday.com/articles/300878.php

Rhonda talks about creating heat shock proteins using saunas. Interesting...

Her blog: https://foundmyfitness.com/ iTunes: https://itunes.apple.com/us/podcast/foundmyfitness/id818198322?mt=2
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RichardS
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Re: New Alzheimer's treatments may arise from modeling 'heat shock proteins'

Postby RichardS » Tue Oct 13, 2015 5:57 pm

It looks like exercise can also affect heat shock proteins in human brains in vivo:
Full text: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1065286/
Exercise induces the release of heat shock protein 72 from the human brain in vivo
G. I. Lancaster,1 K. Møller,2 B. Nielsen,3 N. H. Secher,4 M. A. Febbraio,1 and L. Nybo3
Author information ► Article notes ► Copyright and License information ►
This article has been cited by other articles in PMC.
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Abstract

The present study tested the hypothesis that in response to physical stress the human brain has the capacity to release heat shock protein 72 (Hsp72) in vivo. Therefore, 6 humans (males) cycled for 180 minutes at 60% of their maximal oxygen uptake, and the cerebral Hsp72 response was determined on the basis of the internal jugular venous to arterial difference and global cerebral blood flow. At rest, there was a net balance of Hsp72 across the brain, but after 180 minutes of exercise, we were able to detect the release of Hsp72 from the brain (335 ± 182 ng/min). However, large individual differences were observed as 3 of the 6 subjects had a marked increase in the release of Hsp72, whereas exercise had little effect on the cerebral Hsp72 balance in the remaining 3 subjects. Given that cerebral blood flow was unchanged during exercise compared with values obtained at rest, it is unlikely that the cerebral Hsp72 release relates to necrosis of specific cells within the brain. These data demonstrate that the human brain is able to release Hsp72 in vivo in response to a physical stressor such as exercise. Further study is required to determine the biological significance of these observations.


There are a lot of heat shock proteins of which I basically know nothing, but maybe this is part of the benefit of exercise on the aging brain.

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Re: New Alzheimer's treatments may arise from modeling 'heat shock proteins'

Postby Kathleen1 » Wed Oct 14, 2015 11:46 am

In any case, the heat shock protein articles lets me luxuriate in the sauna. Like coffee, chocolate, music---so many good things good for you. Please now tell me that the sauna provides me with the same benefits as exercise.

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Re: New Alzheimer's treatments may arise from modeling 'heat shock proteins'

Postby KatieS » Wed Oct 14, 2015 2:50 pm

Richard, do you think if we exercise well over the 60% max (i.e. 80% for 40 minutes), produce the HSP benefits earlier than "180 minutes of exercise"? Am I correctly reading 3 hours of exercise at 60%max?

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Re: New Alzheimer's treatments may arise from modeling 'heat shock proteins'

Postby RichardS » Thu Oct 15, 2015 1:45 pm

Kitano wrote:Richard, do you think if we exercise well over the 60% max (i.e. 80% for 40 minutes), produce the HSP benefits earlier than "180 minutes of exercise"? Am I correctly reading 3 hours of exercise at 60%max?


I'm viewing this as a proof of concept piece rather than a source of guidance about the intensity of exercise needed.


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