Huge thanks to all for weighing in. I’ve been looking at this from all different angles and sort of have a plan for ME…for now. I’m convinced that this is yet another case of one-size-fits-all NOT applying to our population
First, thanks for sharing about your Mom, Kit. I was particularly interested in her POST-menopausal levels as I suspect she’s an excellent example of an E4 with longevity biomarkers. It sounds like you don’t have that information but given the relatively low dose of E2 that she takes, we can presume that they are lowish- 30’s maybe??? If you ever get her levels checked, please share. I suspect we can all learn something. Did she use HRT during the transition to menopause? Out of pure curiosity, I’d also love to know her IGF-1 level. I suspect that’s also low. She’s a remarkable example to us all and her health bodes very well for you.
Yes, I agree with you all that estrogen levels fluctuate with transdermal dosing, but testing still provides us with “something." The most reliable data is probably a combination of actual testing and symptoms. Based on that formula, I’m guessing my levels are currently in the low 50s and I feel BAD with a higher level. My breasts and belly are so swollen and bloated. I feel hungry all of the time. (Estrogen increases ghrelin.) And, did I mention the zit on my chin? I feel like I’m fourteen…in a bad way. I feel weighted down, sluggish, less cognitively sharp. It would be ludicrous for me to ignore this & keep trying to raise levels.
I suspect that my estrogen levels are as low as they are (despite supplementing) because of caloric restriction. Practitioners seem to have lower hormone levels, which is supposed to be a part of the benefit. There seem to be two schools of thought with the anti-aging philosophies. One is to try to normalize hormone levels with supplementation to match that of a younger person. Drs. Bredesen and Trutt seem to follow this school. The second philosophy is that of slowing down the systems within the body to slow down the aging process via caloric restriction. Dr. Gundry seems to follow this approach. (BTW, Circ, when I referred to Gundry’s advice for “our population” I simply meant post-menopausal women.) FWIW, I found this link (based on very limited non-human evidence) suggesting that caloric restricted women should NOT supplement estrogen: http://calorierestrictiondietplan.com/g ... -estrogen/
Sigh. Given my much greater propensity for cognitive decline, coupled with my history of severe hot flushes (low cerebral hypometabolism) following that advice probably isn’t a smart option for me.
Jean, excellent observation about the importance of ratios. Mine are all out of whack. My testosterone is fine at 1.4 pg/dL, but my progesterone is sky high at 6.1 ng/mL despite only taking 100 mg at night. I’m going to have to switch to a compounded version and cut my dose in half. I plan to keep my estrogen supplementation steady and NOT work on increasing levels. If my cognition worsens, I can work on up-regulating levels to help address the problem. Arbitrarily increasing them now, when I feel good, feels counterproductive to my strategy. Have I mentioned, I’m a work-in-progress? LOL. Huge thanks for the help, friends.