Paper Access Help: Assoc of ApoC3 Loss-of-Function Mutations w/ Plasma Lipids & Subclinical Athero.

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thumperama
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Paper Access Help: Assoc of ApoC3 Loss-of-Function Mutations w/ Plasma Lipids & Subclinical Athero.

Postby thumperama » Tue Oct 27, 2015 2:49 pm

Does anyone have access to this publication?

http://content.onlinejacc.org/article.a ... ID=2465343

I'm very curious about the question that is asked in the summary: "1) do these mutations also associate with lower plasma low-density lipoprotein cholesterol (LDL-C)"

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RichardS
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Re: Paper Access Help: Assoc of ApoC3 Loss-of-Function Mutations w/ Plasma Lipids & Subclinical Athero.

Postby RichardS » Tue Oct 27, 2015 5:24 pm

It looks like that issue is not yet in PubMed, so I can't use my usual access point. Sorry. If nobody else can get it now, bump up this topic in a few weeks or PM me.

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thumperama
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Re: Paper Access Help: Assoc of ApoC3 Loss-of-Function Mutations w/ Plasma Lipids & Subclinical Athero.

Postby thumperama » Thu Oct 29, 2015 10:22 pm

Richard,

Thanks so much for the reply.

I contacted the lead researcher / author. He is hoping to post it on his lab's website. He offered to contact me when he does.

Chris

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Julie G
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Re: Paper Access Help: Assoc of ApoC3 Loss-of-Function Mutations w/ Plasma Lipids & Subclinical Athero.

Postby Julie G » Fri Oct 30, 2015 3:25 pm

Hey Chris, I found this fairly recent ApoC3 paper (full-text) by the same team. Per the data reported, it looks like this mutation DOES lead to reduced LDL-C.
http://www.kathiresanlab.org/wp-content ... d-2014.pdf


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