Matisse, thanks for posting this risky SNP. However, as another GG, I read the risks as 6.1% vs 2.5% within the five year study, not a six-fold increase. Since the men did not have this increased risk, high estrogen levels are cited as the culprit. This confirms that I'm making the right decision elect very minimal estrogen replacement (0.0125 mg). Like you, I think I'll compare the carotid intimal measurement to the 0.6/0.7 from a few years ago soon.