http://www.statnews.com/2015/11/05/anti ... te-cancer/You might think that while antioxidants are a bad idea for cancer patients, they should help healthy people by preventing DNA damage that can trigger malignancies in the first place. Unfortunately, cancer turns out to be more prevalent than once thought: Many of us have undiagnosed micromalignancies that the immune system and other defenses keep in check. As a result, megadoses of antioxidants — in pills, not pomegranates — might be risky for everyone.
JulieAnnie wrote:Watch out for supplementing with L-methionine according to the following study. I cut back snacking on Brazil nuts as they have a very high level.
Is L-methionine a trigger factor for Alzheimer’s-like neurodegeneration?: Changes in Aβ oligomers, tau phosphorylation, synaptic proteins, Wnt signaling and behavioral impairment in wild-type mice.
Tapia-Rojas, C; Lindsay, CB; Montecinos-Oliva, C; Arrazola, MS; Retamales, RM; Bunout, D; Hirsch, S; Inestrosa, NC
Background: L-methionine, the principal sulfur-containing amino acid in proteins, plays critical roles in cell physiology as an antioxidant and in the breakdown of fats and heavy metals. Previous studies suggesting the use of L-methionine as a treatment for depression and other diseases indicate that it might also improve memory and propose a role in brain function. However, some evidence indicates that an excess of methionine can be harmful and can increase the risk of developing Type-2 diabetes, heart diseases, certain types of cancer, brain alterations such as schizophrenia, and memory impairment. Results: Here, we report the effects of an L-methionine-enriched diet in wild-type mice and emphasize changes in brain structure and function. The animals in our studypresented 1) higher levels of phosphorylated tau protein, 2) increased levels of amyloid-β (Aβ)-peptides, including the formation of Aβ oligomers, 3) increased levels of inflammatory response,4) increased oxidative stress, 5) decreased level of synaptic proteins, and 6) memory impairment and loss. We also observed dysfunction of the Wnt signaling pathway. Conclusion: Taken together, the results of our study indicate that an L-methionine-enriched diet causes neurotoxic effects in vivo and might contribute to the appearance of Alzheimer’s-like neurodegeneration. Electronic supplementary material: The online version of this article (doi:10.1186/s13024-015-0057-0) contains supplementary material, which is available to authorized users.
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