circular wrote:I think there are connective tissues in the neurons (and every other cell!). I've often wondered what affect that might have on EDS/E4 brains.
Dr. Bredesen's recent interview with STEM-Talk mentions some of the neurotrophic factors that, when not available or doing their job, combine to signal to the brain to start programmatic cell death. One he mentioned was extracellular matrix problems. I think but am not sure that the matrix would include connective tissue?viewtopic.php?p=26365#p26365
To be clearer about the HLA EDS gene though, there have been genes identified for most well characterized forms of EDS except
for the most common, hypermobile EDS. So the gene mentioned here with respect to EDS probably doesn't apply if someone has the hypermobile version. The tenascin gene is sometimes mistaken stated to be behind hypermobile EDS, but it's found only rarely in a subset. The Library of Medicine doesn't mention HLA genes among those it attributes forms of EDS to, and neither does this paper about hypermobile EDS, which explains that it's driven by genes that code for proteins and enzymes involved in collagen biosynthesis (http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512326/
); i.e., not genes like HLA involved with inflammation.
At the same time, unless he's changed, I think Dr. Afrin, the mast cell specialist/hematologist, believes that the ligamentous laxity in the common hypermobile EDS is caused by excessive mast cell activation remodeling the collagen with the chemical mediators released by the mast cells. This might help explain later onset cases like mine, especially where there are other signs of excessive mast cell activity, and be of a more immune nature. But genes associated with mast cell activity, to the best of my humble knowledge, also are not HLA genes. They're associated with KIT and others that 'encode proteins for various signaling pathways, epigenetic regulators, the RNA splicing machinery, and transcription factors'. http://www.croh-online.com/article/S1040-8428(14
So I'm not really sure how an HLA gene got attached to EDS?
ApoE 3/4 > Thanks in advance for any responses made to my posts.