Intriguing new mitochondrial research...

[Julie G]

Supporting mitochondria (and thereby staving off oxidative stress) appears to suppress neuronal death- independent of amyloid accumulation. WOW... feels important.
http://www.eurekalert.org/pub_releases/ ... 022516.php

[circular]

Wow, it also provides an excellent, simple description of AD in the brain for newcomers.

[Stavia]

Wow. Another smoking gun. I am more and more convinced over the past year that mitochondria are crucial.

[J11]

This is very impressive!

Yet, I am constantly disappointed at how long it takes to move science forward.
The use of triphenylphosphonium cations is a widely used and often extremely effective
approach to moving things into the mitochondria. The original research for cerium oxide nanoparticles
was published in 2013. Did it really take 3 years to add the TPP?

[Stavia]

J11 it takes a decade for new advances in medicine to be incorporated into daily clinical practice. At least. That's the reality.

[J11]

Yes, but what I found especially discouraging about this story was that it took years and years to simply move forward an idea within pre-clinical research. The idea of adding cerium oxide to the TPP cation is extremely obvious. Similar chemical modifications have been done many many times before and has been shown to be a very effective delivery system into the mitochondria. The TPP cation has been described as being similar to a tug boat. With the positive cation it is very reasonable to see that it will head for the mitochondria.

I really have to wonder, though, did this research really need 2 1/2 years to be published?

[Stavia]

Yip. It is what it is.

[LG1]

This is a very broad question but does anyone have information on what we can do if anything ...exercise, supplements, nutrition… to support our mitochondria? Is that even possible? Maybe if you point me to a study or even forum link on the topic?

Awesome article, very exciting study.

[hill dweller]

LG1 asked for info re mitochondrial support:

Generally, I'm loathe to purchase self-published material, but The Alzheimer's Antidote is an exception. The author (Amy Berger) gathers most of the available info in one spot, albeit at a 40,000 mile view. I'd recommend beginning with her more technical Appendix B, at page 175, but it's good if you start at the beginning, too. She covers brain physiology, insulinemia, ApoE4 implications, nutrigenics (keto and supplements).
http://www.tuitnutrition.com/

[J11]

Hmm, perhaps you don't need to wait for cerium oxide TPP... when you can already get CoQ TPP.
Looks like the NIH has now picked up on this one.
MitoQ has been out there for quite a while and momentum is building.

Wonder what the NIH knows about MitoQ that we don't.

https://alzheimersnewstoday.com/tag/mitoq/

{This alzheimersnewstoday looks like a very high quality site. Sort of like All Alzheimer's ... All the time.
They're our kinda people.}

I am not totally sure how these supplements can simply bypass the clinical trial process and head to the
supplement market. I do not entirely object, though I am unclear how this would be legal. Perhaps the argument
is that the ingredients are essentially GRAS and so why not? This gives these companies a fair chance to actually
make money from their products, while also giving government agencies the opportunity to finance winners after
they have proven themselves for a few years. Wonder whether this route to market will also be used with
cerium oxide TPP? Save quite a bit of money and time if they decided not to bother with a full set of clinical trials.

Helped brain cells from Alzheimer mice.
http://www.ncbi.nlm.nih.gov/pubmed/20463406

Helped Alzheimer mice.
http://www.ncbi.nlm.nih.gov/pubmed/22049413

Helped C.elgans AD model.
http://www.ncbi.nlm.nih.gov/pubmed/24637264


We have mentioned mitochondrial biogenesis a few times on the thread.
https://en.wikipedia.org/wiki/Mitochondrial_biogenesis

Surprisingly they have apparently found something (available online that actually can generate new mitochondria--PQQ)
https://en.wikipedia.org/wiki/Pyrroloquinoline_quinone

More speculatively, there has been some discussion that mitochondria might actually be able to float and move around the body.
I suppose there would be quite a few people interested in a mitochondrial transplant (would be very cool, preferably CRISPRed)