B12 Supplementation and COMT

Alzheimer's, cardiovascular, and other chronic diseases; biomarkers, lifestyle, supplements, drugs, and health care.
Posts: 53
Joined: Sun May 04, 2014 4:44 pm

B12 Supplementation and COMT

Postby Matisse » Sun Feb 28, 2016 6:23 pm

Could anyone give me some guidance on supplementation for B12? I am double homozygous Met/Met for COMT V158M and H62H. I am heterozygous for VDR Bsm and VDR Taq, which I understand are also related to dopamine. The only MTHFR mutation I have is A1298C, which as I understand it, does not affect homocysteine. Okay, here's my problem: When I supplement with methylcobalamin I become very tired (too much dopamine?) and when I supplement with hydroxycobalamin as suggested for COMT Met/Met ++, I feel wired. In the meantime my B12 has now gone down to 163 because I am reluctant to use either form, and I need to do something about it. Any guidance, experience, suggestions, thoughts? Thanks so much.

User avatar
Senior Contributor
Senior Contributor
Posts: 2801
Joined: Wed Oct 30, 2013 7:33 am
Location: Central Florida

Re: B12 Supplementation and COMT

Postby SusanJ » Sun Feb 28, 2016 7:31 pm

Have you tried the adenosylcobalamin form?

Return to “Prevention and Treatment”

Who is online

Users browsing this forum: No registered users and 7 guests