My understanding is that all primates are ApoE4/4, but, I have read (sorry have no link!) that their ApoE4 *acts like* ApoE3. Now wouldn't it seem this should be a critical angle of research? But I see little of it. My thinking is that they sleep well, exercise all the time, eat loads of plant vegetables and greens (?), and are living harmoniously with nature and in a near constant state of mindfulness (?), at least compared with our abstract brains.
Maybe mindfulness mediation is a state that doesn't require as much glucose as abstract cognition, and/or it affects the expression of the ApoE4 gene (see meditation topic below) while sleeping and exercise clear amyloid.
Primates and 4/4
Primates and 4/4
ApoE 3/4 > Thanks in advance for any responses made to my posts.
Re: Primates and 4/4
Interesting observation, Circ.
IF primate's 4/4 acts like a 3/3; could it be because their diet/lifestyle never evolved like human's did? To explain, humans originated with the 4/4 genotype. There is evidence that the E3 and E2 mutations were evolutionary reactions to moving from a hunter/gatherer lifestyle to a more agrarian lifestyle. By and large, primates still eat their intended diet- which surprisingly isn't ALL plant-based http://www.allaboutwildlife.com/what-do-chimps-eat
Another hopeful thing to keep in mind, E4s in developing countries, don't go on to develop AD. There is much evidence that this is a disease of civilization/wealth. Maybe, we can implement that strategy by working hard, staying physically active, and eating whole foods (lots of plants!)...less than we need
IF primate's 4/4 acts like a 3/3; could it be because their diet/lifestyle never evolved like human's did? To explain, humans originated with the 4/4 genotype. There is evidence that the E3 and E2 mutations were evolutionary reactions to moving from a hunter/gatherer lifestyle to a more agrarian lifestyle. By and large, primates still eat their intended diet- which surprisingly isn't ALL plant-based http://www.allaboutwildlife.com/what-do-chimps-eat
Another hopeful thing to keep in mind, E4s in developing countries, don't go on to develop AD. There is much evidence that this is a disease of civilization/wealth. Maybe, we can implement that strategy by working hard, staying physically active, and eating whole foods (lots of plants!)...less than we need
Re: Primates and 4/4
E4s in developing countries not getting AD is interesting. I'm interested in seeing those studies and *which* developing country populations they studied. I think some eat a lot of grains with veggies, others more meat. Then there are wealthy people in the cities of developing countries. What do they eat? No doubt some have adopted the SAD, but I suspect developing country diets are quite varied, so do ApoE4s in developing world not get AD regardless of their diet?
ApoE 3/4 > Thanks in advance for any responses made to my posts.
Re: Primates and 4/4
I wish I could point you to a specific study that connects the dots...but I don't know of one. Here's a starting place, to help find the E4s http://onlinelibrary.wiley.com/store/10 ... 7c8146d766
From what I understand re.diet in developing countries; it's not necessarily one specific diet...but rather the traditional pattern of eating whole local foods, sparingly, paired with physical labor. Once Westernized dietary habits (sugar, flour, industrial seed oils, etc.) and less active lifestyles are largely adopted, Western disease (AD/CVD) seem to follow.
From what I understand re.diet in developing countries; it's not necessarily one specific diet...but rather the traditional pattern of eating whole local foods, sparingly, paired with physical labor. Once Westernized dietary habits (sugar, flour, industrial seed oils, etc.) and less active lifestyles are largely adopted, Western disease (AD/CVD) seem to follow.
Re: Primates and 4/4
Another one re. distribution of apoE4-
http://www.ncbi.nlm.nih.gov/pubmed/17092867
http://www.ncbi.nlm.nih.gov/pubmed/17092867
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Doctor Lost
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Re: Primates and 4/4
Apo E4 and longevity
http://www.plosone.org/article/info%3Ad ... 83CDBB01E2
Humans live substantially longer than our primate cousins. they say E4 is the ancestral allele and E2 and E3 have heightened longevity, possible due to the benefits of grandparenting.
http://www.plosone.org/article/info%3Ad ... 83CDBB01E2
Humans live substantially longer than our primate cousins. they say E4 is the ancestral allele and E2 and E3 have heightened longevity, possible due to the benefits of grandparenting.
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Doctor Lost
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Re: Primates and 4/4
From this article, it sounds like the E4 carriers fare better in one area - a decent, hearty liver! Since all of our nutrients pass through the liver, and I am taking a statin, this is good news. I get tested every 6 months for possible liver damage due to taking simvastin. So, far - and after years of taking this stuff - my liver has always been A-Okay. Does this have something to do with my primal ancestors needing a great liver to process the extra fatty fats they were eating?
Re: Primates and 4/4
I think this is what you're looking for.circular wrote:My understanding is that all primates are ApoE4/4, but, I have read (sorry have no link!) that their ApoE4 *acts like* ApoE3.
McIntosh AM, Bennett C, Dickson D, et al. The apolipoprotein E (APOE) gene appears functionally monomorphic in chimpanzees (Pan troglodytes). PLoS One 2012;7:e47760.
http://www.ncbi.nlm.nih.gov/pmc/article ... rt=article
From the abstract:
Previous studies comparing human and chimpanzee APOE sequences found that the chimpanzee sequence is most similar to the human E4 allele, although the resulting chimpanzee protein might function like the protein coded for by the human E3 allele.
...
We found no coding variation within and between chimpanzee populations, suggesting that the maintenance of functionally diverse APOE polymorphisms is a unique feature of human evolution.
Re: Primates and 4/4
Hi James -
So, we didn't evolve and inherit 4/4 from the primates? Our own human thing? So comparisons to primates mean absolutely nothing. I was just hoping for a decent liver out of the lousy 4/4 deal.
So, we didn't evolve and inherit 4/4 from the primates? Our own human thing? So comparisons to primates mean absolutely nothing. I was just hoping for a decent liver out of the lousy 4/4 deal.
