I don't because I am skeptical of the conventional wisdom that low serum lipids are a surrogate for mortality risk.Juliegee wrote:When I learn about the benefits of SFA, however, I feel conflicted knowing the general effect it has upon our population's advanced lipids... Do you share my qualms?
The whole paper is worthwhile, and I particularly encourage careful review of the four results tables.PMC3750440 wrote:The current study aimed to test whether having levels of TC and its subfractions within the recommended target goals at baseline provided a survival difference in a general population of older adults. The most striking finding was that compared with the reference levels, high TC, HDL-C, or LDL-C levels were associated with lower mortality in the elderly and this was the case for even very high levels. The finding that high TC or LDL-C levels were associated with a lower mortality is contrary to the general assumption that there is a higher mortality among subjects with high lipoprotein levels. Our findings could seem controversial. However, most studies performed in older adults show an inverse association between TC and mortality [11,14] and a recent study demonstrated an inverse association between TC and non-cardiovascular mortality in a population free of CVD and statin use at baseline . These findings were significant from the age of 65 years and were largely due to an inverse association with non-HDL-C. Our study demonstrates the same significant inverse association between high levels of TC and its subfractions and mortality in all age groups from as early as 50 years.
The evidence for a causal relationship between hyperlipidaemia and development of CVD is overwhelming [2,24]. However, our data indicate that a major part of the general population aged 50 + has lipoprotein levels above the recommended levels and that those groups without CVD or diabetes at measurement have a survival benefit compared with the groups with the recommended low levels.
Given the mortality reduction associated with the low triglycerides / high cholesterol scenario, I think my ApoE4-typical lipid production response to saturated fats may well be a sign that I benefit disproportionately from a generous supply of non-oxidized serum lipids.
As I see it, mainstream thought in these forums runs something like this:
-A lipid profile consisting of low triglycerides, low total cholesterol, and high HDL (and low calculated LDL) is safe. As long as triglycerides are low, high total cholesterol, high calculated LDL, and high LDL-P may or may not be safe.
-Eating saturated fat raises serum cholesterol for E4 carriers.
-Therefore, minimizing saturated fat is safer for E4 carriers.
Juliegee wrote:x Can someone have an LDL-P of 2,000 and low levels of small LDL-P or sdLDL and low glycemic markers?
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