Viktor I'm so glad you're bringing more voices out about your perspective. We need to hear everyone's experience, since it really helps with appreciating how varied our own biochemical responses can be to a given diet. Then there's the interpretation of what those variances indicate or imply, in all dietary contexts, which can get complex. We often but not always act, consciously, without sufficient data to unequivocally support what we're doing. This is the nature of being e4 today, because unfortunately the AD research community has not been focused on our unique genotype, even though it's the largest known genetic susceptibility impact on late onset AD. It does seem like there's an increase of awareness in the research community that more attention needs to focus on e4, and all studies in AD should genotype participants. One purpose of our group is to beat the drum and help drive this shift. Meanwhile, during the time this forum has been active, some years now, new findings are continually being published that give us food for thought. Some 'things' are moving further along the spectrum from hypothesis to confirmation, but most 'things' need more study in large RCTs. Our uncertainty applies to all diets except, really, the SAD full of processed food (there maybe different takes on what's good/bad processed at the edges, e.g. EVOO). There have been some recent, decently well-designed dietary studies (hard to come by given the challenges of dietary studies!) focused on or addressing AD prevention: FINGER, MIND, and PREDIMED come to mind.
Would a strict vegan diet bring about better outcomes for some? Not sure, but I read Campbell years ago and was vegan and had terrible gut issues. Now I work with Dr. Gundry, so the large balance of my diet is vegan and mostly raw, but in addition it's very low lectin while vegans generally eat a very high lectin diet. I modify his approach slightly. I do eat salmon (dark fish) twice a week for food-sourced omega 3 (I have a homozygous SNP that significantly impairs conversion of linolenic acid to omega 3), and my protein is about 40 grams, give or take, because I'm currently trying to build muscle and recover from surgery. I also have a hard time staying satiated, even in mild ketosis (although that's better), and I'm not losing the small amount of belly fat that I should in ketosis, so I need to cut back the fat calories and achieve better satiation. That leaves protein and my gut doesn't tolerate plant proteins at all. I'm very sensitive to lectins and always have been, not just gluten and dairy: all grains and legumes, and now, I'm learning many vegetables too. So that's not a yes to whether anyone else on the forum is vegan, but to explain that I've been there, done that, and strict vegan doesn't work for me. That's not even addressing glucose and insulin levels on a high carb, even if whole food, intake. With the known e4 hypometabolism of glucose I don't want to take my chances by running higher glucose as opposed to making ketones available as fuel for my brain. Many people experience better cognition in ketosis, supporting this perspective that the brain prefers ketones as fuel (although there are parts of the brain that still require their glucose I think).
I hope you'll continue to test new biomarkers that we feel may be very important to e4s to track so we can better assess your status in the context of a vegan diet. I've just been to the lab today to get some that I can't get through my doctor, but I could order them from Life Extension. It's always happy dance time when someone's diet is what they want to eat as well as what their biomarkers suggest to them is good for them to eat
Silverlining thanks for bringing up this older thread. I start reading and I'll have to print it for later. (viewtopic.php?f=29&t=538)
ApoE 3/4 > Thanks in advance for any responses made to my posts.