I warmly invite everyone to take the time to actually listen to the top homocysteine/AD researchers; David Smith (Oxford) & Helga Refsum (University of Oslo) provide the evidence linking elevated homocysteine with dementia. Martha & I were lucky enough to hear them speak last spring in NYC. They make a very compelling case for tracking and tweaking homocysteine as needed to prevent and/or halt brain atrophy and cognitive decline.
Their information was not considered controversial or fringe in any way by the top AD researchers and clinicians in the world. Please see my notes from the meeting here.
Their talks are actually quite entertaining and...motivating
Here's a link to Dr. Smith’s talk & graphics:http://www.nyas.org/MediaPlayer.aspx?mi ... dc3fb81558
Here’s a link to Dr. Refsum’s talk & graphics: http://www.nyas.org/MediaPlayer.aspx?mi ... 8875d97723
Per these top researchers, the following supplements below provide the starting
place for addressing elevated
homocysteine (>7 or 8 µmol/ for our high risk population.) This works for most
people, not all as Susan will soon share with us in an upcoming Wiki entry. Tracking & tweaking individual B levels gets a lot more tricky and is sometimes necessary. Additionally, we have evidence that higher levels (above current reference ranges) of various B vitamins are sometimes necessary to get the homocysteine lowering effect.
-1 mg cobalamin
-800 mcg of folate/5-methyltetrahydrofolate or 5-MTHF
-20 mg of B-6/pyridoxal 5’ phosphate
To my knowledge there is no B vitamin complex that provides this combination at these levels. Please share if you’ve found one. TMG can be added if this protocol is unsuccessful. It’s also important to keep in mind that this trifecta of Bs is more likely to benefit those with an adequate Omega-3 Index (DHA being more important than EPA) per recent evidence
from Smith & Refsum. This information may be very relevant for vegans with high homocysteine.