Ski wrote:Im conflicted by the information on whether one needs both THC and CBD for the neuroprotective effects or is CBD alone sufficient?
As I tried to convey in the wiki, CBD seems to help with more health concerns of interest to ApoE4 than THC does: inflammation, insulin resistance, stress, sleep (although THC in combination with CBD seems to be the best answer here), and hormonal balance. All of those feed into neuroprotection/brain health.
I THINK (remember one layperson’s opinion) that CBD is more important. Most of the studies I found (in the deeper dive section – Cannabinoids and Alzheimer’s) seemed to address CBD’s protective qualities, not THC, but then maybe that’s because research with CBD is easier? Research does indicate that THC has qualities that might help with plaque clearance and regaining brain “youth,” but recognize those studies have been mice studies which don’t always translate to humans.
I know Dr Nasha Winters, an integrative oncologist and co-author of “The Metabolic Approach to Cancer” recommends CBD but not THC for brain cancer patients. She gets a lot of information from her biochemist husband. He works at one of the independent testing labs certified by the Colorado Marijuana Enforcement Division. He recently gave a presentation on CBD at a conference which was, as described in the Heads up Health podcast interview with Dr Winters as a “drop the mike” presentation. I hope it was recorded because I’m dying to find it and listen to it, but I’m not sure it was.
CBD is certainly easier to get obtain. THC dosage seems to be critical when trying to gain the proper medical benefit, whereas, if a person takes too much CBD, as long as it’s a quality product, there’s not much of a down side except for the expense and possible gastrointestinal issues, which I understand only comes with very high doses.
Personally, I’m leery of THC products out there because the lack of regulation. It’s not your grandpa’s marijuana anymore. Marijuana has been cultivated with significant THC increase since the 1960s and is being grown for max production/sales inducing who knows what other contaminants. I know here in Colorado, where both recreational and medical marijuana is legal, there have been product recalls due to pesticide content. So grow your own organically, but a “byproduct” of those growing their own marijuana indoors can be mold and we know mold is brain toxic.
Okay, this is just one anecdote, but earlier this year my hairdresser’s father (late 50s or maybe early 60s) smoked some marijuana and shortly thereafter suffered a seizure where he severely dislocated his shoulder. He had no history of seizures. He was a regular, lifelong marijuana user. Did he get a product with “something extra” that didn’t work well with his body or was this simply a coincidence, we’ll never really know.