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Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Posted: Wed Jun 29, 2016 11:16 am
by simonh01
http://www.eurekalert.org/pub_releases/2016-06/si-crp062816.php

LA JOLLA -- Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer's disease.

While these exploratory studies were conducted in neurons grown in the laboratory, they may offer insight into the role of inflammation in Alzheimer's disease and could provide clues to developing novel therapeutics for the disorder.

"Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer's, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells," says Salk Professor David Schubert, the senior author of the paper.

Alzheimer's disease is a progressive brain disorder that leads to memory loss and can seriously impair a person's ability to carry out daily tasks. It affects more than five million Americans according to the National Institutes of Health, and is a leading cause of death. It is also the most common cause of dementia and its incidence is expected to triple during the next 50 years.

It has long been known that amyloid beta accumulates within the nerve cells of the aging brain well before the appearance of Alzheimer's disease symptoms and plaques. Amyloid beta is a major component of the plaque deposits that are a hallmark of the disease. But the precise role of amyloid beta and the plaques it forms in the disease process remains unclear.

In a manuscript published in June 2016's Aging and Mechanisms of Disease, Salk team studied nerve cells altered to produce high levels of amyloid beta to mimic aspects of Alzheimer's disease.

The researchers found that high levels of amyloid beta were associated with cellular inflammation and higher rates of neuron death. They demonstrated that exposing the cells to THC reduced amyloid beta protein levels and eliminated the inflammatory response from the nerve cells caused by the protein, thereby allowing the nerve cells to survive.

"Inflammation within the brain is a major component of the damage associated with Alzheimer's disease, but it has always been assumed that this response was coming from immune-like cells in the brain, not the nerve cells themselves," says Antonio Currais, a postdoctoral researcher in Schubert's laboratory and first author of the paper. "When we were able to identify the molecular basis of the inflammatory response to amyloid beta, it became clear that THC-like compounds that the nerve cells make themselves may be involved in protecting the cells from dying."

Brain cells have switches known as receptors that can be activated by endocannabinoids, a class of lipid molecules made by the body that are used for intercellular signaling in the brain. The psychoactive effects of marijuana are caused by THC, a molecule similar in activity to endocannabinoids that can activate the same receptors. Physical activity results in the production of endocannabinoids and some studies have shown that exercise may slow the progression of Alzheimer's disease.

Schubert emphasized that his team's findings were conducted in exploratory laboratory models, and that the use of THC-like compounds as a therapy would need to be tested in clinical trials.

In separate but related research, his lab found an Alzheimer's drug candidate called J147 that also removes amyloid beta from nerve cells and reduces the inflammatory response in both nerve cells and the brain. It was the study of J147 that led the scientists to discover that endocannabinoids are involved in the removal of amyloid beta and the reduction of inflammation.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Posted: Wed Jun 29, 2016 7:24 pm
by Tiramisu1984
Dr. Kogan mentioned this during our appointment.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Posted: Thu Jun 30, 2016 1:48 am
by TheBrain
I am pleased to see this. I find marijuana to be a great stres reducer, and it gets me in touch with my intuition. During my last three years in Colorado, I was a medical marijuana patient. I like to think that my marijuana use protected my neurons while I unknowingly was oxygen deprived during sleep from living at high altitude (9100 feet).

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Posted: Thu Jun 30, 2016 11:14 am
by marthaNH
Should be a scene in a remake of Sleeper. "And marijuana makes you smarter, it turns out."

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Posted: Thu Jun 30, 2016 7:52 pm
by GenePoole0304
I read an article earlier that explained how difficult the researchers wanting to do legit research are restricted by the drug laws causing delays and limiting dosage.

Well it is good for migraines too, although I have not tried it.

http://www.ncbi.nlm.nih.gov/pubmed/9696453

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Posted: Thu Jun 30, 2016 8:01 pm
by Julie G
Hope it's my cure for CIRS ;).

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Posted: Thu Jun 30, 2016 8:19 pm
by apod
This stuff seems pretty interesting:
http://www.biocbdplus.com/

Although, it seems pretty low-dosed and high-priced. All the benefits, minus the high? :D
https://en.wikipedia.org/wiki/Adult_neu ... nnabinoids

Apparently there is some effort to breed very low THC plants expressing high CBD genetics.
https://www.projectcbd.org/alzheimers-disease

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Posted: Fri Jul 01, 2016 3:01 am
by Gilgamesh
Yet another reason to come to Colorado in August.

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Posted: Fri Jul 01, 2016 3:31 am
by Stavia
Oh...it's legit right????

Re: Cannabinoids remove plaque-forming Alzheimer's proteins from brain cells

Posted: Fri Jul 01, 2016 6:01 am
by TheBrain
Stavia wrote:Oh...it's legit right????


Yes, recreational marijuana is now legal in Colorado. But we can't legally bring any purchases home with us if we live out of state (or out of country!).