the TyrRS-PARP-1 pathway can be measurably activated by much lower doses of resveratrol -- as much as 1,000 times lower -- than were used in some of the more celebrated prior studies, including those focused on SIRT1. "Based on these results, it is conceivable that moderate consumption of a couple glasses of red wine (rich in resveratrol) would give a person enough resveratrol to evoke a protective effect via this pathway"
The only evidence is that resveratrol at supplement dosage is simply a very expensive anti-oxidant. I would be very curious to hear from a doctor who recommends it what they're basing the recommendation on.
The work followed a 2013 study by Bredesen and Rao, along with geneticist Veena Theendakara, which showed a connection between ApoE4 and Alzheimer's via the anti-aging protein Sirtuin1 (SIRT1), the same molecule whose activity is enhanced by resveratrol, an ingredient in red wine. The presence of ApoE4 triggered the reduction of SIRT1 both in neural cells and in the brains of Alzheimer's patients with ApoE4. How ApoE4 triggered the reduction of SirT1 was not explained in that study.
ApropoE4 wrote:Cancer sometimes causes fever.
Ibuprofen is a good treatment for fever.
Ibuprofen is not a good treatment for cancer.
Ibuprofen at 1mg/day is not a good treatment for anything.
Results showed a significant exponential decline in the risk with increasing intake of NSAIDs (primarily aspirin or ibuprofen) for 7-10 malignancies including the four major types: colon, breast, lung, and prostate cancer. Daily intake of NSAIDs, primarily aspirin, produced risk reductions of 63% for colon, 39% for breast, 36% for lung, and 39% for prostate cancer. Significant risk reductions were also observed for esophageal (73%), stomach (62%), and ovarian cancer (47%). NSAID effects became apparent after five or more years of use and were stronger with longer duration. A few studies suggest that ibuprofen has stronger anticancer effects than aspirin, particularly against breast and lung cancer. Our findings indicate that ibuprofen at the concentrations of 100, 200, 300, 400, and 500 μM is able to reduce the cancerous characteristics of the AGS cells by inducing apoptosis, inhibition of cell proliferation, and angiogenesis. Real-time RT-PCR showed that ibuprofen altered the expression of several genes including Akt, P53, PCNA, Bax, and Bcl2 in the AGS cells. In addition, reduction in CD44 and OCT3/4 transcript levels revealed that ibuprofen reduces the stemness of the AGS cells and therefore it could be used as a potential anti-tumor drug.
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