"Although this Phase 2 study was not designed nor powered to provide meaningful estimates of anti-dementia efficacy, both the ADAS-Cog and the CGI-I scales in the study yielded positive signals of enhanced efficacy. ...
“Pre-clinical studies have repeatedly shown that there is a strong dose/efficacy relationship associated with AChEIs. Further, PET scan studies in humans show that at the typical dose of 10 mg/day of donepezil, the central enzymatic inhibition is no greater than about 30 percent, substantially lower than that which would be expected from optimal dosing. Yet, historically, it has not been possible to tolerably increase the dose of donepezil to meaningfully higher levels,” "
Fairly impressive that this was in moderate AD.
Is Aricept considered effective in severe AD?
"Aricept is a prescription medicine to treat mild, moderate, and severe Alzheimer’s disease"
Looks like the solifenacin Aricpet combo will be a topic of discussion at the next doctor's appointment.
Would Quadruple strength Aricept be effective in severe AD?
Last edited by J11
on Sat Jul 30, 2016 7:21 pm, edited 2 times in total.