L-serine research

Alzheimer's, cardiovascular, and other chronic diseases; biomarkers, lifestyle, supplements, drugs, and health care.
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Re: L-serine research

Postby Fiver » Tue Jan 22, 2019 7:53 am

I love that the secret weapon is algae. :)

Just read these papers by coincidence and I really related to the story line, probably because of my love of ethnobotany.

It is interesting that the original cause was algae (cyanobacteria, or blue/green algae) that produce the toxin which was bio-accumulated up the food chain to the flying foxes. And one prevention could be seaweeds with high serine contents.

Who knows if this story is any different than the others which didn't pan out. But it makes some sense to me. This reminds me of the use of lysine to reduce outbreaks of hsv viruses, by shifting the balance of lysine vs arginine away from the amino acid the virus needs. Here the serine just prevents the toxic non-protein amino acid from getting into the protein chains and causing problems.

My cabinet is pretty full but this one seems to be worth following.
Reading studies, need coffee. All I know: it's beautifully terribly complex. It's really a miracle that any of it works at all. Being healthy, but sometimes this mess of billions of neurons has had enough avocados and just wants a crunchy cookie.

Its Me
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Re: L-serine research

Postby Its Me » Sun Feb 10, 2019 7:16 pm

Thanks all for posting. Earlier today I posted about the Fortune article over on the Our Stories forum and asked if anyone heard of this. And they pointed me here. Didn't realize it was such old news, yet trials are due. The list of foods is pretty much what I eat (except eggs), and I agree it'd be hard to get the amount from just food. Maybe move to Okinawa and eat tofu and seaweed and drink their water.

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Re: L-serine research

Postby Karina52 » Sat Feb 16, 2019 5:33 pm

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Joined: Mon Apr 23, 2018 3:13 pm

Re: L-serine research

Postby Verax » Sun Mar 31, 2019 3:10 pm

Maybe zinc works like serine? https://www.clinicaltrials.gov/ct2/show/NCT01259050 . But I don't understand the applicability to AD, as Cox's research points to a motor neuron disease, ALS, or Lytico-bodig disease, and the description from Guam of connection to BMAA is a lytico paralysis ending in a bodig dementia "like AD". The vervet study of BMAA showed neurdegeneration like AD but not ALS. I think there is room for more controversy and Cox and allies need better research before applying to AD treatment or prevention.

Thus I am especially alarmed at the paper today "Cyanobacterial neurotoxin BMAA and brain pathology in stranded dolphins" at https://doi.org/10.1371/journal.pone.0213346 that found BMAA and beta amyloid in stranded dolphin brains. BMAA are mostly produced by cyanobacteria, and dolphins like humans are at the top of the food chain, but all the links from the bottom to top of that chain haven't been filled in for BMAA and its isomers. And BMAA measurements haven't been sufficiently standardized. It seems most likely to me that there are many factors including heredity behind both AD and BMAA susceptibility. And now enviromental politics.

https://www.sciencealert.com/beached-do ... -to-us-all comments
"these creatures [dolphins] may very well be our first indication of poor environmental conditions, and while it's still not clear if these blooms directly lead to Alzheimer's in dolphins or in humans, the researchers say it's a risk we shouldn't be willing to take. "The $64,000 question is whether these marine mammals experienced cognitive deficits and disorientation that led to their beaching," says co-author Paul Alan Cox, an ethnobotanist at the Brain Chemistry Labs in Jackson Hole. Until further research clarifies this question, people should take simple steps to avoid cyanobacterial exposure."

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