Re: Calorie restriction (CR)
Posted: Thu Aug 21, 2014 7:25 pm
J,
Jetlagged and on prednisone (long story...), but briefly:
No, my concern is more general. Honestly, it's hard for me to know what to do with these discussions about dietary fat without having any isocaloric intervention trial data, nor even well-conducted, very large-scale epidemiological, isocaloric comparisons. Eat more fat, have delayed gastric emptying, feel fuller, eat less, get improved biomarkers because you're eating less (which is hormetic)! Pure CR. If you can do it like the Okinawans do (huge carb-intake), same result. So, I have no "concern" about low carb, except that we may have completely misidentified its mechanism.
Of course, good data on isocaloric diets with different levels of fat might be out there. (And maybe it's even been posted here -- if so, sorry I missed it!) Until I can review it, I feel like I can't say anything meaningful.
GB
P.S.
Julie, my God, THANK YOU for doing so much at the Facebook site! (https://www.facebook.com/apoe4.info) Wow!
Jetlagged and on prednisone (long story...), but briefly:
No, my concern is more general. Honestly, it's hard for me to know what to do with these discussions about dietary fat without having any isocaloric intervention trial data, nor even well-conducted, very large-scale epidemiological, isocaloric comparisons. Eat more fat, have delayed gastric emptying, feel fuller, eat less, get improved biomarkers because you're eating less (which is hormetic)! Pure CR. If you can do it like the Okinawans do (huge carb-intake), same result. So, I have no "concern" about low carb, except that we may have completely misidentified its mechanism.
Of course, good data on isocaloric diets with different levels of fat might be out there. (And maybe it's even been posted here -- if so, sorry I missed it!) Until I can review it, I feel like I can't say anything meaningful.
GB
P.S.
Julie, my God, THANK YOU for doing so much at the Facebook site! (https://www.facebook.com/apoe4.info) Wow!