Thanks Susan.
Stavia, I found this report from "Global Council on Brain Health". The Appendix, Section 8 has a long list of references on exercise and dementia. (re building some primer content around this subject)
http://www.aarp.org/content/dam/aarp/he ... ection.pdf
http://www.exeter.ac.uk/research/newsan ... 88_en.html (another reference)
Research on the Hazda and exercise
Re: Research on the Hazda and exercise
MAC
E3/E4-59/MALE
E3/E4-59/MALE
Re: Research on the Hazda and exercise
Thanks Mac! You are awesome.
It would be fabulous if you had the time at some stage to do a wiki article on this topic.
It would be fabulous if you had the time at some stage to do a wiki article on this topic.
Re: Research on the Hazda and exercise
Wiki article, certainly. Can someone oversee the build, happy to generate the raw content.
MAC
E3/E4-59/MALE
E3/E4-59/MALE
Re: Research on the Hazda and exercise
Exercise, APOE genotype, and the evolution of the human lifespan (2014)
https://www.ncbi.nlm.nih.gov/pmc/articl ... 576184.pdf
[MAC] Essentially, our increased longevity evolved ancestrally when we developed aerobic/endurance capabilities, and the current mismatch between heritage and modern diet/sedentary lifestyle, especially for E4's, is a key causative agent for neurodegenerative diseases.
"Here, we have developed a hypothesis for the evolution of the human lifespan that shows how increases in aerobic activity during our transition from a low-activity, sedentary, apelike lifestyle, to a high-activity hunter-gather lifestyle served to relax constraints on aging imposed by the deleterious homozygous APOE ε4 genotype. These studies provide an evolutionary context that suggests that diseases such as CAD, AD and other age-related dementias, may be due, in part, to the mismatch between our genetic heritage and our modern environment. We believe that the evolutionary hypothesis detailed here sheds important light on current ideas for prevention of CAD and AD. The genetic risk imposed by the ε4 allele may be particularly high among individuals leading sedentary lifestyles, with physical activity equalizing disease risk among all genotypes. Without a continued lifestyle of high physical activity, regions of the world where the ε4 allele remains highly prevalent (e.g., equatorial Africa with ε4 frequencies approaching 50%) may experience a substantial increase in CAD, AD, and dementia with the increasing globalization of sedentary lifestyles.
Life expectancy versus lifespan and the evolution of human longevity
Among living hunter-gatherer groups, modal age of death ranges from 68 to 78 years, compared with a modal age of death of 85 years in the USA, and 15 years in wild chimpanzees. In traditionally living human groups, most deaths in the total population, and in the population over the age of 60, are due to infectious illness or injury rather than to a degenerative disease. Thus, in humans living lifestyles similar to those of our ancestors, modal lifespans are longer than that of our closest relatives, the chimpanzee. Although debates over when these long lifespans evolved continue, data from both paleodemography and life-history theory suggest that a shift towards longer lives occurred sometime during the evolution of the genus Homo. Lifespans of living hunter-gatherers support this notion that human longevity may have evolved early in our lineage, possibly with the transition to the hunter-gatherer lifestyle that marks the origins of Homo erectus 1.8 million years ago"
https://www.ncbi.nlm.nih.gov/pmc/articl ... 576184.pdf
[MAC] Essentially, our increased longevity evolved ancestrally when we developed aerobic/endurance capabilities, and the current mismatch between heritage and modern diet/sedentary lifestyle, especially for E4's, is a key causative agent for neurodegenerative diseases.
"Here, we have developed a hypothesis for the evolution of the human lifespan that shows how increases in aerobic activity during our transition from a low-activity, sedentary, apelike lifestyle, to a high-activity hunter-gather lifestyle served to relax constraints on aging imposed by the deleterious homozygous APOE ε4 genotype. These studies provide an evolutionary context that suggests that diseases such as CAD, AD and other age-related dementias, may be due, in part, to the mismatch between our genetic heritage and our modern environment. We believe that the evolutionary hypothesis detailed here sheds important light on current ideas for prevention of CAD and AD. The genetic risk imposed by the ε4 allele may be particularly high among individuals leading sedentary lifestyles, with physical activity equalizing disease risk among all genotypes. Without a continued lifestyle of high physical activity, regions of the world where the ε4 allele remains highly prevalent (e.g., equatorial Africa with ε4 frequencies approaching 50%) may experience a substantial increase in CAD, AD, and dementia with the increasing globalization of sedentary lifestyles.
Life expectancy versus lifespan and the evolution of human longevity
Among living hunter-gatherer groups, modal age of death ranges from 68 to 78 years, compared with a modal age of death of 85 years in the USA, and 15 years in wild chimpanzees. In traditionally living human groups, most deaths in the total population, and in the population over the age of 60, are due to infectious illness or injury rather than to a degenerative disease. Thus, in humans living lifestyles similar to those of our ancestors, modal lifespans are longer than that of our closest relatives, the chimpanzee. Although debates over when these long lifespans evolved continue, data from both paleodemography and life-history theory suggest that a shift towards longer lives occurred sometime during the evolution of the genus Homo. Lifespans of living hunter-gatherers support this notion that human longevity may have evolved early in our lineage, possibly with the transition to the hunter-gatherer lifestyle that marks the origins of Homo erectus 1.8 million years ago"
MAC
E3/E4-59/MALE
E3/E4-59/MALE
Re: Research on the Hazda and exercise
MAC, if you can generate a document with all your studies and the information you've posted with them, them I'll slap it into the wiki.
Think this is so important, it's one of those areas we need to organize and publish.
Think this is so important, it's one of those areas we need to organize and publish.
