Interesting review article from 2014 about AD in Sub-Saharan Africa:
https://www.hindawi.com/journals/ijad/2014/195750/
How Not to Die
Re: How Not to Die
Great points about the age issue, karelena.
Re: How Not to Die
Good point K.
Also the region-specific genetic variants is no small matter. At the opposite end of vegans using this study to support their agenda is the hflc community often referring to the high fat diet among healthy Eskimos as 'evidence' that hflc is okay if not superior. Sometime in the last couple years or so they identified a genetic variant the Eskimos had that helped them handle their very high fat diet. On my phone, so hard to go looking for it.
Also the region-specific genetic variants is no small matter. At the opposite end of vegans using this study to support their agenda is the hflc community often referring to the high fat diet among healthy Eskimos as 'evidence' that hflc is okay if not superior. Sometime in the last couple years or so they identified a genetic variant the Eskimos had that helped them handle their very high fat diet. On my phone, so hard to go looking for it.
ApoE 3/4 > Thanks in advance for any responses made to my posts.
Re: How Not to Die
Regarding the Yoruba study, they only looked at confirmed AD cases, so lifespan is not an issue. As I mentioned in a previous post, E4/4 in the Yoruba population had the same chance of developing AD as E4/4 African-Americans in Indianapolis. The diet/lifestyle component seemed to make a difference for E3/4, where in Yoruba the E3/4 looked like E3s, and in Indianpolis E3/4 are midway between E4/4 and E3s.
I completely agree with all the statements about people with an agenda misusing this paper. In the end, I think all you can say is that the American diet/lifestyle is probably worse for E3/4s, which is not news to anybody here.
By the way, I was able to find free text on the study from Ecuador saying that E4 does not seem to affect AD rates. It's underpowered which may explain the lack of effect. It also explained that the E4 rate in Ecuador is among the lowest in Latin America. An different publication indicated that Ecuador had a high E4 rate.
This all just goes to show how little we really know.
I completely agree with all the statements about people with an agenda misusing this paper. In the end, I think all you can say is that the American diet/lifestyle is probably worse for E3/4s, which is not news to anybody here.
By the way, I was able to find free text on the study from Ecuador saying that E4 does not seem to affect AD rates. It's underpowered which may explain the lack of effect. It also explained that the E4 rate in Ecuador is among the lowest in Latin America. An different publication indicated that Ecuador had a high E4 rate.
This all just goes to show how little we really know.
Re: How Not to Die
"This all just goes to show how little we really know."
THat is why we not only need more reseach dollars but we really need more people to be tested especially african american, latinos, native americans, and the rest of us mostly Heinz 57's like me. 23 and me seems like a likely place to begin focusing on more research especially with their paired ancestors information.
THat is why we not only need more reseach dollars but we really need more people to be tested especially african american, latinos, native americans, and the rest of us mostly Heinz 57's like me. 23 and me seems like a likely place to begin focusing on more research especially with their paired ancestors information.
APOe 3/4; If you want to go fast go alone. If you want to go far go together. African proverb.
Re: How Not to Die
Sorry I missed when posted, Julie. Still love Ms. Minger's ability to dissect other claims objectively. Just wanted to note that I continue to also believe myself that her summary statement most coherently fits the full array of data we presently have.Juliegee wrote:Denise Minger does a great job of reviewing Dr. Michael Greger’s new book, How Not to Die, in this recent article. Her review is both complimentary and critical, pointing out his tendency to “cherry pick” the evidence to support his hypotheses. There’s an excellent section on diet and dementia, with some focus on ApoE4.But what about genetics? Here, too, Greger serves up a plant-based solution with a bowl of picked cherries.
...
So, deactivating apoE4 as a ticking Alzheimer’s bomb may have less to do with plant-based eating and more to do with common features of hunter-gatherer lifestyles: feast-famine cycles, high physical activity, and unprocessed diets that aren’t necessarily limited to plants (39).
Russ
E3/4
Eat whole, real, flavorful food - fresh and in season... and mix it up once in a while.
E3/4
Eat whole, real, flavorful food - fresh and in season... and mix it up once in a while.
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Re: How Not to Die
At the IFM conference Terry Wahls posted a global Alzheimer's prevalence map of the earth sourced from the WHO in 2011. I can't remember from the lecture whether there was any reason given for the worldwide discrepancy, but the US, Canada, England, Western Europe, and Australia looked like they had the worst prevalence. Could toxins also be a factor in the higher numbers?
Maureen
Maureen
Re: How Not to Die
Here's a table I cobbled together between AD cases per 100000 people and ApoE4 allele rates (% of population with at least 1 allele):
USA, Switzerland, Belgium, and Spain jump out to me as having disproportionately lower E4 rates vs. more AD cases. Finland has both the highest AD rate in the world and the highest E4 rate outside of Africa. Sweden has a similar E4 rate to Finland, but lower AD rate. I've mentioned this here in other posts, and some have suggested a particularly high rate of alcohol use in Finland vs. Sweden could be a contributing factor.
A caveat here is that the larger and more genetically diverse countries like the U.S. are a bit harder to pin down. The E4 rate is likely to be higher and lower in some pockets.
Sources:
http://www.worldlifeexpectancy.com/caus ... y-country/
http://www.researchgate.net/publication/6704176
Code: Select all
Rank Country AD Rate E4 Allele rate
1 FINLAND 53.77 0.215
2 USA 45.58 0.110
3 CANADA 35.5 0.150
4 ICELAND 34.08 0.164
5 SWEDEN 32.41 0.205
6 SWITZERLAND 32.25 0.109
7 NORWAY 30.24 0.174
8 DENMARK 29.53 0.170
9 NETHERLANDS 29.32 0.154
10 BELGIUM 27.23 0.128
11 SPAIN 26.9 0.094
12 AUSTRALIA 25.91 0.165
13 FRANCE 25.62 0.114
14 UK 24.35 0.129
15 CUBA 22.38 0.130
16 CHILE 21.03 0.137
17 URUGUAY 20.74 not reported
18 ISRAEL 19.9 0.151
19 NEW ZEALAND 19.02 0.141
20 IRELAND 17.7 0.171
A caveat here is that the larger and more genetically diverse countries like the U.S. are a bit harder to pin down. The E4 rate is likely to be higher and lower in some pockets.
Sources:
http://www.worldlifeexpectancy.com/caus ... y-country/
http://www.researchgate.net/publication/6704176