Thanks Julie for bumping up while I'm pondering my response. Due to my severe Raynauds, I opted for a calcium channel blocker (CCB) nifedipine based on study
, but evidence for nifedipine over the more commonly used amlodipine hasn't been replicated and the research was sponsored by nifedipine. I wrote the author a few times without a response. Possibly, amlodipine might be more effective. Although Julie's article did not support CCB; this recent study
had the dementia prevention for CCB and angiotensin blockers (ARB) equivalent (OR .56 to .60 respectively).
Sparrow, if not for the Raynauds, I would switch back to an ARB. However, while on losartan, my B/P plummeted ~85/60 and had mild positional lightheadedness. So with your weight loss and decreasing insulin resistance, whatever you take, monitor with a home cuff and have your doctor agree upon how to adjust the dose. Due to a fractured knee as a teenager, I have knee osteoarthritis, so I have looked if the CCB would benefit, theoretically
but nothing solid. Any weight bearing joints will greatly benefit from the weight loss. One major downside for me is that the nifedipine should not be taken with curcumin which did decrease my knee pain. Actually all the CCB are metabolized by the liver's CYP3A4, but the interaction with curcumin is "minor", so I have a Tumeric/Ginger tea, not the mega-dose I was taking before. I think with continued weight loss and CPAP treatment (me too), your pain will diminish even more.