Hi, all. I just had to add a second BP medication to keep my (inherited) blood pressure under control, and tomorrow I need to see my doctor for the followup. I am worried about whether I should take this drug. It's a calcium channel blocker called DILT-XR for diltiazem. Looks like a good drug far as I can tell, and I've been fine with it the week-plus that I've been on it. But I found one source that tells me that the calcium channel blockers nifedipine and diltiazem are believed to have anticholinergic effects -- they are both ranked either as Low Activity or 1's on a 0 to 3 scale designed to measure anticholinergic burden. None of the other CCBs are listed, far as I can tell. But as far as I know the only reason I don't have information on all the others might be that they haven't been tested. So what would you do? Get off the drug immediately? Keep taking it for a while and do more research? Switch to one of the CCBs that is not listed? I am already taking an ACE inhibitor, am maxed out on the dosage and have no side effects, but I have to add some drug. I kind of don't like the sound of beta blockers. I'm 62, active, 3/4, normal weight, no cardiac issues to speak of besides the hypertension. The source is a Pharmacist's Letter titled "Drugs with Anticholinergic Activity" published in 2011 by Therapeutic Research Center. I downloaded it and now can't trace it back to the original web site. I have been careful not to take any anticholinergics for the last 4 years or so -- since I found this web site -- but I did take them in the past. About 20 years ago I was taking Claritin every day for quite a while -- months not weeks. Does the "burden" of the past factor into present-day decisions? Interested in what you would do.
PS I found this study [https://www.ncbi.nlm.nih.gov/pubmed/27392121
] that seems to support the idea that amlodipine may be better for dementia than other CCBs, but they didn't compare CCBs to other alternatives, like a diuretic or something.