Rs5963409 - hypertension / vascular health

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aphorist
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Rs5963409 - hypertension / vascular health

Postby aphorist » Mon Oct 30, 2017 7:46 am

This SNP is worth looking at more closely. https://www.snpedia.com/index.php/Rs5963409
G is the normal (preferred) variant
A is the abnormal (poorly functioning) variant.

This SNP for the Ornithine Carbamoyltransferase gene is involved in the urea cycle and ultimately creates citrulline (later arginine) for nitric oxide production and removes nitrogen (from protein metabolism waste/byproduct) from the body for excretion.

Image
This gene is X-chromosome linked and therefore males only have 1 copy. It is associated with an increase in hypertension and alzheimer's, but may suggest a lower protein diet is preferred given a (possible) innate reduced ability to clear nitrogen and produce urea.

Supplementation with arginine or citrulline may be warranted.

This gene polymorphism is discussed by Dr. Chris Masterjohn in this presentation linked here:

https://youtu.be/lrhR5fWp5ps?t=20m30s

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Re: Rs5963409 - hypertension / vascular health

Postby SusanJ » Mon Oct 30, 2017 8:22 am

Interesting stuff. Anyone who has been on the forum for a whiles know that we all react differently to diet, and there are a many genetic reasons why. Here's another example.

I'm hetero, which makes sense since my mom had hypertension as did her siblings. Fortunately my BP is low-normal, but snpedia says the elevated risk for AD is the same whether hetero- or homozygous.

But Masterjohn also makes an important point. That FM practitioners tend to look at results of tests and say take this vitamin or supplement, when maybe the approach needs to be, hey, try eating less protein (in this case) and see if you feel better.

Here is his ending slide, which seems like some great advice for all of us, especially since most of us have some forms of enzymatic deficiencies.

Screen Shot 2017-10-30 at 8.04.09 AM.png
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Re: RE: Re: Rs5963409 - hypertension / vascular health

Postby ajc » Mon Oct 30, 2017 2:59 pm

SusanJ wrote:Interesting stuff. Anyone who has been on the forum for a whiles know that we all react differently to diet, and there are a many genetic reasons why. Here's another example.

I'm hetero, which makes sense since my mom had hypertension as did her siblings. Fortunately my BP is low-normal, but snpedia says the elevated risk for AD is the same whether hetero- or homozygous.

But Masterjohn also makes an important point. That FM practitioners tend to look at results of tests and say take this vitamin or supplement, when maybe the approach needs to be, hey, try eating less protein (in this case) and see if you feel better.

Here is his ending slide, which seems like some great advice for all of us, especially since most of us have some forms of enzymatic deficiencies.

Screen Shot 2017-10-30 at 8.04.09 AM.png
This situation is the time for OAT or other metabolic testing to see what is happening in the pathways regardless of SMPs

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Re: Rs5963409 - hypertension / vascular health

Postby SusanJ » Mon Oct 30, 2017 3:09 pm

ajc wrote:This situation is the time for OAT or other metabolic testing to see what is happening in the pathways regardless of SMPs


Hi ajc, have you done OAT, and if so, where you able to take actionable steps?

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Re: RE: Re: Rs5963409 - hypertension / vascular health

Postby ajc » Tue Oct 31, 2017 4:10 pm

SusanJ wrote:
ajc wrote:This situation is the time for OAT or other metabolic testing to see what is happening in the pathways regardless of SMPs


Hi ajc, have you done OAT, and if so, where you able to take actionable steps?
Yes these tests give an over view of metabolic health above and beyond SNPs. Treating the patients as individuals. Helps in prioritizing treatments

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