Welcome to the party!
The overwhelmingly positive results from the various Methylene blue/LMTX trials should now be recognized by our forum as essentially a cure or near cure for AD. The figure above from the Taurx website shows that those with mild AD on Methylene blue in the phase 2 trial (with the 138 mg dose) had nearly stable cognitive scores for at least two years. This trial was originally announced at an ICAD meeting almost ten years ago and was recently published. (Notice that the below article on this trial found all sorts of complexities with MB dosing and apparently the correct dosing and how food should be incorporated into the treatment schedule have not been fully resolved.)
This is a very impressive result.
This is not merely a symptomatic treatment.
It would not be unreasonable to call this disease modification.
The result was then replicated (though with caveats) in two follow on phase 3 trials using a chemically similar molecule LMTX.
The second phase 3 trial was recently published in the Journal of Alzheimer Disease (TRx-005 below). The treatment effects and statistical significances were very large. There was a large reduction in brain atrophy for those treated with LMTX monotherapy. For those with APOE 4 the difference was possibly even larger than average. This is not a placebo effect. The p values for many of the measures were <= 0.0001. These were for arms of n < 80. If they had combined the three separate comparisons, the statistical significance level would have been more or less 0.
Let the party begin!
Phase 2 articlehttp://taurx.com/phase-2.html
Phase 3 TRx-005 Mild AD
Phase 3 TRx-015 Mild-Moderate AD
(full free text is at http://taurx.com/phase-3.html
for some reason I am unable to upload this file.)
Phase 3 -- TRx-007 bvFTD
Even in this trial which had a top line negative result the treatment group and placebo did better than expected versus historical controls. All the patients received LMTX some at 4 mg bid some at 100 mg bid. Yet, in this trial 80% were not on concurrent AD drugs. http://taurx.com/trx-237-007-phase-3-cl ... update.pdf
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