Wow, Giftsplash. . . what an emotional ride you've been on! I'm so sorry about that and so VERY glad it ended the way it did!! Did your ApoE4 result change as well?
I've been on the same painful journey to find out if I am at risk for early onset as well. I am 50 years young with confirmed e3/e4 (based on 23andMe and confirmed through Boston Heart labs). I have two other markers: one for PSEN1 (it's the SNP recognized as protective - unfortunately, I do NOT have it) and one for APP.
There are other gene markers that are under investigation for AD - the common ones I found on many sites are: APP, PSEN1, PSEN2, MAPT, CLU, CR1, PICALM and TREM2. There are many others that are currently being reviewed.
I am currently working with a Bredesen trained doc - I was officially diagnosed with MCI (mild cognitive impairment) last week, so a PET Scan and an MRI with Neuro Quant are now scheduled. Prayers welcomed!!
I understand why many ask about familial AD - yet, our family did not see it. That's because, quite unfortunately, most of my ancestors died young (mostly from heart disease). . . so my gut tells me they all died BEFORE
AD reared its ugly head. My parents died quite young - my mother was sickly most of her adult life (obese since I was born - she also had uncontrolled diabetes and died at age 66 after multiple (mini) heart attacks which lead to congestive heart failure). My father had a quad-bypass in his mid 60s and then a stroke - he died in his sleep at age 72. My maternal grandmother died of a massive heart attack at 39 and the remaining grandparents died in their 60s/70s (all heart issues!!). All of my aunts and uncles have died (6 of them - many had diabetes, two died from massive heart attacks in their 50s, three died of heart issues in their 60s and only one died from liver cancer in her early 70s (although she had heart issues!)). As far as I know, only one had an autopsy. I should add: I am the baby of 16 cousins - 5 have died already (2 from cancer, although they had heart issues) and only one has made it past the ripe old age of 60 (yet she is in a rehab center - had a stroke in her mid-50s and recently had heart surgery!). YIKES - scary stuff!!!!!!
I appreciate the information J11 posted earlier about Ancestry.com and the other GEDMatch site - I am definitely looking into that.
I'm sharing all of this to enlighten others who read this post and are concerned about early onset - just because AD is not in your family history, that does NOT mean you are not at risk (especially if you carry one or two ApoE4 allele along with the other gene markers).
I welcome any and all feedback on this subject!