viaswiss wrote:I also have the PPAR-a polymorphism and it makes me wonder if intermittant fasting or ketosis is worth it.
There's an interesting speculative discussion on the Pete Attia's podcast wtih Rhonda Patrick. They discuss PPAR alpha and gamma. Then they go on to discuss saturated fats. PPAR alpha folks should strive for a higher ratio of monounsaturated fats and polyunsaturated fats to saturated fats, in particular if they intend to fast or go into ketosis. Peter has seen a pattern where there is a subset of people (10-20%) on a ketogenic diet who have problems, in particular LDL-P goes way up and inflammation markers go up. Those people are making much more cholesterol, he says. He goes on to wonder if this subset is the same as the people who have PPAR alpha (G allele) . They discussed that there are other SNPs (e.g. FTO) that could be responsible. Rhonda went on to say that people with these SNPs who eat a diet higher in saturated fat than mono+PUFAs have higher inflammation, higher oxLDL, higher sdLDL, and other such markers. Prevalence is probably less than 20%.https://peterattiamd.com/rhondapatrick/
I can say that as I worked through a Paleo diet, I ramped up my saturated fat intake (e.g. cooked with bacon grease) and my total cholesterol measurements went up from about 175 to 250, with LDL being the big increase but HDL went up too. When I took my first True Health Diagnostics (THD) test that included the advanced markers, where I unexpectedly learned about my APOE status, it showed my LDL-P at 1905 and sdLDL at 44. So I cut my saturated fat back and my next LDL-P was at 1529 while my total cholesterol dropped to 205 and sdLDL to 28. Recently I had another test and the sdLDL had dropped to 26 (unfortunately, I didn't get any other lipid markers).
I'd be interested if others seem to be hyper-responders to saturated fat and their PPAR-alpha status. I am rs1800206 (C;G).