Woo hoo- another SNP that may offer protection...

Alzheimer's, cardiovascular, and other chronic diseases; biomarkers, lifestyle, supplements, drugs, and health care.
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Julie G
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Woo hoo- another SNP that may offer protection...

Postby Julie G » Fri May 02, 2014 1:23 pm

This may explain why some with the pathology don't go on to develop symptoms:
http://news.vanderbilt.edu/2014/04/stud ... esiliency/

Anybody brave enough to check? :?

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Re: Woo hoo- another SNP that may offer protection...

Postby Gina99 » Fri May 02, 2014 1:39 pm

I am not finding that SNP on snpedia or in the V3 or V4 chip.


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KatieS
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Re: Woo hoo- another SNP that may offer protection...

Postby KatieS » Fri May 02, 2014 2:06 pm

Just checked, I'm rs4728029AG. Looks like you can only be A or G phenotype. Which genotype is protective against brain inflammation?

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Julie G
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Re: Woo hoo- another SNP that may offer protection...

Postby Julie G » Fri May 02, 2014 3:35 pm

You BRAVE girls gave me courage to look. I'm AG, like you, Kit. No tears or cheers :roll: From what I can glean G is the ancestral allele. The article refers to a mutation. IF the authors are using that term correctly, the golden ticket would be: AA (Please correct me if I'm wrong!)

http://www.ncbi.nlm.nih.gov/projects/SN ... rs=4728029

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Re: Woo hoo- another SNP that may offer protection...

Postby Gina99 » Fri May 02, 2014 4:00 pm

Oh duh, I found it. The 3 of us are AG.

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Re: Woo hoo- another SNP that may offer protection...

Postby bentkat » Fri May 02, 2014 4:48 pm

Bummer!
I'm GG :oops:

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Re: Woo hoo- another SNP that may offer protection...

Postby Gilgamesh » Sat May 03, 2014 5:21 am

The Vanderbilt article -- is that the one you mean? -- says:

One genetic mutation (rs4728029) was found to relate to both ventricle dilation and cognition and is a marker of neuroinflammation.


It doesn't say how it relates, but if the mutation is a "marker " of inflammation, it's probably a marker in the "plus" direction (i.e., more inflammation). This would mean the ancestral allele, G, is the better allele.

But it would be good to get the article, or contact the researchers. These university pop summaries are sometimes wrong.

GB

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Julie G
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Re: Woo hoo- another SNP that may offer protection...

Postby Julie G » Sat May 03, 2014 8:10 am

G, I think you are right. If anyone is able to get the paper & confirm for us- that would be amazing.

Bentkat, it may be time for a victory lap on the 'bent :D Cheers to outliving us all!

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Re: Woo hoo- another SNP that may offer protection...

Postby Doctor Lost » Sat May 03, 2014 9:15 am

Hmmm, I'm also Heterozygous on this SNP and was born with congenital hydrocephalus...Maybe there's something to this one. There's also a body of work confusing normal pressure hydrocephalus and AD

http://www.ncbi.nlm.nih.gov/pubmed/?ter ... heimer%27s

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Re: Woo hoo- another SNP that may offer protection...

Postby bentkat » Sat May 03, 2014 1:21 pm

Julie,

I might have a long life but I hope that I still have some of my brain cells when I'm old.


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