Woo hoo- another SNP that may offer protection...

Alzheimer's, cardiovascular, and other chronic diseases; biomarkers, lifestyle, supplements, drugs, and health care.
J11
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Re: Woo hoo- another SNP that may offer protection...

Postby J11 » Thu May 22, 2014 8:03 pm

The article claims that the A allele is the risk variant.

This negative effect might be related to the POT1 lowering influence of the A allele. ( Lower POT1 levels have been associated with shorter telomeres. The article explains that shorter telomeres have been related to AD risk. )

The figures in the article show that A/A carriers had increased left inferior lateral ventricle dilation ( with respect to ptau ), decreased memory performance, and decreased IL-6 receptor (anti-inflammatory) response relative to the A/G and G/G genotypes. A significant difference is not evident between the A/G and G/G genotypes on these measurements (though there might be a small advantage for the G/Gs). However, the article is not clear whether the G/G genotype is advantageous relative to the A/G genotype.

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Julie G
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Re: Woo hoo- another SNP that may offer protection...

Postby Julie G » Thu May 22, 2014 8:14 pm

Welcome J1 1! Thanks for your input. Took some time... but we eventually figured it out ;) How'd you fare?

sarahb12
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Re: Woo hoo- another SNP that may offer protection...

Postby sarahb12 » Sat May 24, 2014 3:53 pm

AA for me.
E3/E4

Gina99
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Re: Woo hoo- another SNP that may offer protection...

Postby Gina99 » Fri May 30, 2014 7:48 am

Do we have a thread for environmental items? Lead: http://www.lead.org.au/fs/fst48.html



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Julie G
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Re: Woo hoo- another SNP that may offer protection...

Postby Julie G » Fri May 30, 2014 10:31 am

No, Gina- but please start one!

J1 1 (and all,) I moved J1 1's story over to the "Introduction" section of the forum. It deserved it's own topic and will help keep us better organized. Here's a link to the new thread viewtopic.php?f=2&t=473 One important reason for creating this forum was to stay organized and to categorize information for easier reference at a later date. Thanks for your help :D


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