"Seventeen studies that investigated the association between 5 TNF-alpha polymorphisms (-850, -308, -863, -238, and -1031) and AD were retrieved and analyzed...Current findings support an association between -850 C>T polymorphism and the risk of developing AD; hence, they strengthen the suggestion of a potential role for anti-TNF therapy to maintain physiologic levels of TNF-alpha."http://www.ncbi.nlm.nih.gov/pubmed/19445962
"We found a significant asssociation of a TNFR2 exon 6 polymorphism with late-onset AD in families with no individuals possessing the APOE E4E4 genotype under a dominant model. We found no significant association of three polymorphisms in the TNFR1 gene to AD. These results provide further evidence for the involvement of TNF in the pathogenesis of AD."http://www.ncbi.nlm.nih.gov/pubmed/11754994
I'm trying to figure out if these studies specifically studied a gene I just found in Promethease that increases TNF: GMAF rs1800629(A;G) http://www.snpedia.com/index.php/Rs1800629
We've got one study talking "TNF polymorphisms 850, 308, 863 blah blah", another talking "TNFR2 exon 6 polymorphism", and Promethease referring to position rs1800629.
Meanwhile, I thought these "rs" identifications referred to positions on a gene that can show variant alleles, but I keep reading things calling rsblahbalh a gene! Getting confused
ApoE 3/4 > Thanks in advance for any responses made to my posts.